Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57700 | Target Info | |||
| Target Name | Tyrosine-protein kinase Kit (KIT) | ||||
| Synonyms |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; p145 c-kit; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; Mast/stem cell growth factor receptor Kit; CD117 antigen; CD117; C-kit
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| Target Type | Successful Target | ||||
| Gene Name | KIT | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 30 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(3-Methylphenyl)-3-[4-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102648; BDBM50238296
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl4246600
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463456
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779202; SCHEMBL897210; BDBM50344664; 6,6-dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4250883
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463461
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(3-Thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL393862; BDBM50209155
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Chembl4245985
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463455
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Cyclohexyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096138; BDBM50238284
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(3-Thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245734; SCHEMBL4823884; BDBM50209149; 1-(3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole-5-carbonyl)piperidine-3-carboxylic acid
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Chembl4247042
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463458
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Chembl4248043
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463451
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(2-Chlorophenyl)-1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL209971; BDBM50188743
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Chembl4243462
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463454
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Chembl4239846
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463450
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(6,7-Dimethoxyquinazolin-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2388315; CHEMBL3926830
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
Chembl4243810
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463460
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine
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Investigative | Compound Info | ||
| Synonyms |
bispyridinylethylene, 2; pyridine-base inhibitor 1b; CHEMBL383541; SCHEMBL6853457; BDBM15022; trans-bispyridinylethylene analog 2q; Q27096021
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
4-Pyrido[2,3]thieno[2,4-d]pyrimidin-4-yl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2392393; CHEMBL3924103
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
Chembl4250240
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463452
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(2-Methoxyethyl)-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-m-tolylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213270; BDBM50188767
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Chembl4244068
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463453
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(4S,6R,12Z)-6-Bromo-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668417; BDBM50336463
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| Activity |
IC50 = 81000 nM
|
[11] | |||
| Compound Name |
(4S,6R,12E)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668412; BDBM50336466
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(4S,6R,12Z)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668416; BDBM50336464
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| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
1-(2,2-Diethoxyethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799221; SCHEMBL18250089; BDBM50184774
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|
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-[4-Amino-1-(2,2-dimethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800138
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|
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-[4-Amino-1-(1,3-dioxolan-2-ylmethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797590
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
eCF309; eCF-309; eCF 309; GTPL9571; CHEMBL3800481; SCHEMBL22773819; BDBM200300; cid_122163152; AKOS030211008; ZINC585672921; compound 12 [Fraser et al., 2016]; J3.595.265I
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 16 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Lapatinib
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|
Approved | Compound Info | ||
| Synonyms |
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(propan-2-ylamino)ethyl]furan-2-yl]quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344213; BDBM50030384
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344217; BDBM50030378
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(ethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344211; SCHEMBL1352826; BDBM50030382
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|
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] pentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344218; BDBM50030377
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(2-methylsulfonylethylamino)ethyl]furan-2-yl]quinazolin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344214; BDBM50030375
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
6-[5-(1-Amino-2-methylsulfonylethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344209; SCHEMBL1351084; BDBM50030387
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(cyclohexylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344212; BDBM50030388
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
CID 46866615
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344220; SCHEMBL1352619; BDBM50030389
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] heptanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344219; BDBM50030381
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1R)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344221; SCHEMBL1353012; BDBM50030380
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1S)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344216; SCHEMBL1351262; BDBM50030383
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
CID 46866616
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344215; SCHEMBL1351081; BDBM50030385
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|
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(methylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344210; SCHEMBL1353264; BDBM50030379
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|
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344208; SCHEMBL1351264; BDBM50030376
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|
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| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629013; GTPL9989; SCHEMBL22137472; BDBM50128294; AKOS032960466; compound 11 [PMID: 26431428]; Q27455367; 2-(1-Cyclopentyl-5-(1-(oxetane-3-yl)-4-piperidinyl)-1H-pyrazole-3-ylamino)pyridine-4-carbonitrile
Click to Show/Hide
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| Activity |
IC50 = 534000 nM
|
[14] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 2 | Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRalpha) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs). J Med Chem. 2017 Jun 22;60(12):5099-5119. | ||||
| REF 3 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
| REF 4 | Discovery of novel Syk/PDGFR-alpha/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis. Bioorg Med Chem. 2018 Aug 15;26(15):4375-4381. | ||||
| REF 5 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
| REF 6 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 7 | Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3136-40. | ||||
| REF 8 | 1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4266-71. | ||||
| REF 9 | US patent application no. 7326712B2, Substituted tricyclic compounds as protein kinase inhibitors | ||||
| REF 10 | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2000-7. | ||||
| REF 11 | Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1167-70. | ||||
| REF 12 | eCF309: a potent, selective and cell-permeable mTOR inhibitor. Medchemcomm. 2016;7:471-7. | ||||
| REF 13 | Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. Eur J Med Chem. 2014 Nov 24;87:631-42. | ||||
| REF 14 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 22;58(20):8182-99. | ||||
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