Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15051 Target Info
Target Name TNF receptor-associated factor 6 (TRAF6)
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Target Type Literature-reported Target
Gene Name TRAF6
Biochemical Class Acyltransferase
UniProt ID
TRAF6_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name ATP-dependent RNA helicase DDX3X (DDX3X) Interacting Protein Interacting Protein Info
UniProt ID
DDX3X_HUMAN 
Synonyms CAP.Rf; DBX; DDX14; DDX3; HLP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
6 Yeast two hybrid [8]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [11]
2 Yeast two hybrid [12]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Yeast two hybrid [14]
Adapter proteins [+] 3 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [17]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [19]
7 Affinity Capture-Western [20]
8 Co-localization [21]
Interacting Target Name Myeloid differentiation primary response protein MyD88 (MYD88) Literature-reported Target Interacting Protein Info
UniProt ID
MYD88_HUMAN 
Synonyms MyD88
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-Western [22]
Interacting Protein Name Ectodysplasin-A receptor-associated adapter protein (EDARADD) Interacting Protein Interacting Protein Info
UniProt ID
EDAD_HUMAN 
Synonyms ECTD11A; ECTD11B; ED3; EDA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Yeast two hybrid [24]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Biochemical Activity [26]
Kinases [+] 10 Kinases +
Interacting Target Name IL-1 receptor-associated kinase 1 (IRAK1) Patented-recorded Target Interacting Protein Info
UniProt ID
IRAK1_HUMAN 
Synonyms IRAK-1; IRAK; Interleukin-1 receptor-associated kinase 1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [28]
4 Affinity Capture-Western [29]
5 Affinity Capture-Western [30]
6 Affinity Capture-Western [31]
7 Affinity Capture-Western [32]
8 Affinity Capture-Western [33]
9 Affinity Capture-Western [34]
10 Affinity Capture-Western [35]
11 Affinity Capture-Western [36]
12 Affinity Capture-Western [37]
13 Affinity Capture-Western [38]
14 Affinity Capture-Western [39]
15 Affinity Capture-Western [40]
16 Affinity Capture-Western [41]
17 Affinity Capture-Western [42]
18 Affinity Capture-Western [43]
19 Affinity Capture-Western [44]
20 Affinity Capture-Western [45]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Affinity Capture-Western [47]
3 Affinity Capture-Western [48]
4 Affinity Capture-Western [49]
5 Affinity Capture-Western [50]
6 Affinity Capture-Western [51]
7 Affinity Capture-Western [52]
8 Affinity Capture-Western [53]
9 Affinity Capture-Western [54]
10 Affinity Capture-Western [38]
11 Affinity Capture-Western [23]
12 Affinity Capture-Western [43]
13 Affinity Capture-Western [55]
14 Affinity Capture-Western [56]
15 Affinity Capture-Western [57]
16 Affinity Capture-Western [58]
17 Affinity Capture-Western [59]
18 Affinity Capture-Western [60]
19 Biochemical Activity [54]
20 Biochemical Activity [61]
Interacting Target Name TGF-beta receptor type I (TGFBR1) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR1_HUMAN 
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Affinity Capture-Western [62]
3 Biochemical Activity [63]
4 Reconstituted Complex [62]
Interacting Protein Name Interleukin-1 receptor-associated kinase-like 2 (IRAK2) Interacting Protein Interacting Protein Info
UniProt ID
IRAK2_HUMAN 
Synonyms IRAK.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [64]
3 Affinity Capture-Western [37]
4 Affinity Capture-Western [40]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [65]
2 Affinity Capture-Western [66]
3 Reconstituted Complex [67]
Interacting Target Name NF-kappa-B-activating kinase (TBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
TBK1_HUMAN 
Synonyms TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Affinity Capture-Western [69]
3 Reconstituted Complex [69]
Interacting Target Name MAPK/ERK kinase kinase 3 (MAP3K3) Literature-reported Target Interacting Protein Info
UniProt ID
M3K3_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Affinity Capture-Western [70]
3 Co-localization [21]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [72]
Interacting Target Name Mixed lineage kinase 3 (MAP3K11) Literature-reported Target Interacting Protein Info
UniProt ID
M3K11_HUMAN 
Synonyms Src-homology 3 domain-containing proline-rich kinase; SPRK; SH3 domain-containing proline-rich kinase; PTK1; Protein-tyrosine kinase PTK1; MLK3; Mixed-lineage protein kinase 3; Mitogen-activated protein kinase kinase kinase 11
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [73]
2 Biochemical Activity [74]
Interacting Target Name Serine/threonine-protein kinase NIK (MAP3K14) Literature-reported Target Interacting Protein Info
UniProt ID
M3K14_HUMAN 
Synonyms NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14; HsNIK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Co-localization [11]
Peptidases [+] 7 Peptidases +
Interacting Target Name Presenilin 1 (PSEN1) Clinical trial Target Interacting Protein Info
UniProt ID
PSN1_HUMAN 
Synonyms S182 protein; PSNL1; PS-1; PS1; Protein S182; Presenilin-1; AD3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Affinity Capture-Western [76]
3 Affinity Capture-Western [77]
4 Co-localization [78]
Interacting Protein Name Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) Interacting Protein Interacting Protein Info
UniProt ID
MALT1_HUMAN 
Synonyms IMD12; MLT; MLT1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [79]
2 Affinity Capture-Western [80]
3 Biochemical Activity [79]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 20 (USP20) Interacting Protein Interacting Protein Info
UniProt ID
UBP20_HUMAN 
Synonyms LSFR3A; VDU2; hVDU2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [81]
2 Affinity Capture-Western [82]
3 Reconstituted Complex [81]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 4 (USP4) Interacting Protein Interacting Protein Info
UniProt ID
UBP4_HUMAN 
Synonyms UNP; Unph
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [83]
2 Affinity Capture-Western [84]
3 Reconstituted Complex [83]
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [85]
2 Fluorescence Resonance Energy Transfer [86]
Interacting Target Name Herpesvirus ubiquitin-specific protease (HAUSP) Preclinical Target Interacting Protein Info
UniProt ID
UBP7_HUMAN 
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [87]
2 Reconstituted Complex [88]
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Preclinical Target Interacting Protein Info
UniProt ID
UBP2_HUMAN 
Synonyms UBP41; Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Yeast two hybrid [24]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Interferon regulatory factor 7 (IRF7) Interacting Protein Interacting Protein Info
UniProt ID
IRF7_HUMAN 
Synonyms IRF.7H; IRF7A; IRF7B; IRF7C; IRF7H
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [90]
2 Affinity Capture-Western [91]
3 Affinity Capture-Western [92]
4 Affinity Capture-Western [93]
5 Biochemical Activity [92]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [94]
2 Co-localization [95]
3 Reconstituted Complex [94]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [96]
3 Affinity Capture-Western [42]
4 Biochemical Activity [97]
5 Biochemical Activity [98]
6 Biochemical Activity [99]
7 Biochemical Activity [100]
Other proteins [+] 10 Other proteins +
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [101]
2 Affinity Capture-Western [102]
3 Affinity Capture-Western [103]
4 Biochemical Activity [104]
5 Biochemical Activity [99]
6 Biochemical Activity [105]
7 Biochemical Activity [106]
Interacting Protein Name Mitochondrial antiviral-signaling protein (MAVS) Interacting Protein Interacting Protein Info
UniProt ID
MAVS_HUMAN 
Synonyms CARDIF; IPS.1; IPS1; VISA
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [107]
2 Affinity Capture-Western [108]
3 Affinity Capture-Western [109]
4 Affinity Capture-Western [69]
5 Co-crystal Structure [110]
6 Reconstituted Complex [110]
Interacting Protein Name Adapter protein CIKS (TRAF3IP2) Interacting Protein Interacting Protein Info
UniProt ID
CIKS_HUMAN 
Synonyms ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [111]
2 Affinity Capture-Western [58]
3 Affinity Capture-Western [112]
4 Yeast two hybrid [24]
Interacting Protein Name Numb-like protein (NUMBL) Interacting Protein Interacting Protein Info
UniProt ID
NUMBL_HUMAN 
Synonyms CAG3A; CTG3a; NBL; NUMB.R; NUMBLIKE; NUMBR; TNRC23
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [113]
2 Affinity Capture-Western [114]
3 Affinity Capture-Western [115]
4 Reconstituted Complex [113]
Interacting Target Name Low-affinity nerve growth factor receptor (NGFR) Successful Target Interacting Protein Info
UniProt ID
TNR16_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 16; TNFRSF16; P75NTR; P75neurotrophin receptor (p75(NTR)); P75ICD; p75 ICD; NGFreceptor; NGF-P75 receptor; NGF receptor; Lowaffinity neurotrophin receptor p75NTR; Low affinity neurotrophin receptor p75NTR; Gp80-LNGFR; CD271; 75kD-neurotrophin receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [116]
2 Affinity Capture-Western [17]
3 Reconstituted Complex [116]
Interacting Target Name TIR domain-containing adapter molecule 1 (TICAM1) Patented-recorded Target Interacting Protein Info
UniProt ID
TCAM1_HUMAN 
Synonyms TRIF; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; TIR domain-containing adapter protein inducing IFN-beta; TICAM-1; Putative NF-kappa-B-activating protein 502H; PRVTIRB; Proline-rich, vinculin and TIR domain-containing protein B; MyD88-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [117]
2 Reconstituted Complex [118]
3 Yeast two hybrid [119]
Interacting Target Name CD40L receptor (CD40) Clinical trial Target Interacting Protein Info
UniProt ID
TNR5_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 5; TNFRSF5; CDw40; CD40L receptor; Bp50; B-cell surfaceantigen CD40; B-cell surface antigen CD40
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [120]
2 Co-crystal Structure [121]
Interacting Target Name Transmembrane activator and CAML interactor (TNFRSF13B) Clinical trial Target Interacting Protein Info
UniProt ID
TR13B_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 13B; TACI; CD267
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [122]
2 Yeast two hybrid [123]
Interacting Target Name Osteoclast differentiation factor receptor (ODFR) Literature-reported Target Interacting Protein Info
UniProt ID
TNR11_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 11A; Receptor activator of NF-KB; RANK; Osteoclast differentiation factor receptor; ODFR; CD265
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [124]
2 Reconstituted Complex [125]
Interacting Protein Name TIR domain-containing adapter molecule 2 (TICAM2) Interacting Protein Interacting Protein Info
UniProt ID
TCAM2_HUMAN 
Synonyms MyD88.4; TICAM.2; TIRAP3; TIRP; TRAM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [118]
2 Reconstituted Complex [126]
References  Top
REF 1 Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor B (RANK) Signaling Complex Enhances Osteoclastogenesis. J Biol Chem. 2016 Sep 23;291(39):20643-60.
REF 2 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 3 The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. 1999 Jan 15;442(2-3):147-50.
REF 4 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem. 2011 Mar 11;286(10):7905-16.
REF 5 Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol. 2008 Feb 15;376(2):526-40.
REF 6 Isolation and characterization of two novel A20-like proteins. Biochem J. 2001 Aug 1;357(Pt 3):617-23.
REF 7 The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. Sci Signal. 2013 Jun 4;6(278):ra44.
REF 8 YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-B. Elife. 2017 Feb 28;6. pii: e22416.
REF 9 OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J. 2013 Apr 17;32(8):1103-14.
REF 10 K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5. Nat Immunol. 2014 Mar;15(3):231-8.
REF 11 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 12 Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Mol Cell Proteomics. 2012 Jul;11(7):M111.016162.
REF 13 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 14 Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. Nat Genet. 1998 Mar;18(3):287-91.
REF 15 The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000 Apr 3;19(7):1576-86.
REF 16 K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Mol Cell. 2013 Aug 8;51(3):283-96.
REF 17 TRAF6 and p62 inhibit amyloid -induced neuronal death through p75 neurotrophin receptor. Neurochem Int. 2012 Dec;61(8):1289-93.
REF 18 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68.
REF 19 The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. EMBO J. 2006 Aug 9;25(15):3524-33.
REF 20 DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology. 2019 Mar;69(3):1046-1063.
REF 21 PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 2010 Jan 15;285(3):2077-89.
REF 22 A20-binding inhibitor of NF-B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006.
REF 23 Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia. Br J Dermatol. 2013 Mar;168(3):629-33.
REF 24 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 25 Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination. FEBS Lett. 2006 May 29;580(13):3145-52.
REF 26 A Method to Identify p62's UBA Domain Interacting Proteins. Biol Proced Online. 2003;5:228-237.
REF 27 TRAF6 is a signal transducer for interleukin-1. Nature. 1996 Oct 3;383(6599):443-6.
REF 28 A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005 Aug;25(15):6521-32.
REF 29 Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Biochem Pharmacol. 2014 Jun 15;89(4):515-25.
REF 30 IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged s... J Biol Chem. 2001 Aug 3;276(31):29037-44.
REF 31 T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72.
REF 32 IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4461-5.
REF 33 Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling. Biochim Biophys Acta. 2009 Dec;1790(12):1673-80.
REF 34 Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. J Immunol. 2007 Sep 15;179(6):4125-34.
REF 35 PINK1 positively regulates IL-1-mediated signaling through Tollip and IRAK1 modulation. J Neuroinflammation. 2012 Dec 17;9:271.
REF 36 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.
REF 37 IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10.
REF 38 TRIM38 inhibits TNF- and IL-1-triggered NF-B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1509-14.
REF 39 Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J Biol Chem. 2003 Apr 4;278(14):12144-50.
REF 40 IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997 Nov 28;278(5343):1612-5.
REF 41 Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling. Cell Signal. 2008 Apr;20(4):666-74.
REF 42 IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6. Biochim Biophys Acta. 2012 Feb;1823(2):255-63.
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