Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T84791 Target Info
Target Name JUN activation domain binding protein (COPS5)
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Target Type Literature-reported Target
Gene Name COPS5
Biochemical Class Peptidase
UniProt ID
CSN5_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-fractionation [2]
4 Reconstituted Complex [2]
Interacting Protein Name Regulator of nonsense transcripts 1 (UPF1) Interacting Protein Interacting Protein Info
UniProt ID
RENT1_HUMAN 
Synonyms HUPF1; NORF1; RENT1; pNORF1; smg.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [3]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Receptor of activated protein C kinase 1 (RACK1) Literature-reported Target Interacting Protein Info
UniProt ID
RACK1_HUMAN 
Synonyms Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [4]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name DNA damage-binding protein 2 (DDB2) Interacting Protein Interacting Protein Info
UniProt ID
DDB2_HUMAN 
Synonyms DDBB; UV.DDB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [6]
Interacting Protein Name Denticleless protein homolog (DTL) Interacting Protein Interacting Protein Info
UniProt ID
DTL_HUMAN 
Synonyms CDT2; DCAF2; L2DTL; RAMP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
COP9 signalosomes [+] 8 COP9 signalosomes +
Interacting Protein Name COP9 signalosome complex subunit 2 (COPS2) Interacting Protein Interacting Protein Info
UniProt ID
CSN2_HUMAN 
Synonyms ALIEN; CSN2; SGN2; TRIP15
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [8]
3 Co-fractionation [9]
4 Far Western [10]
Interacting Protein Name COP9 signalosome complex subunit 1 (GPS1) Interacting Protein Interacting Protein Info
UniProt ID
CSN1_HUMAN 
Synonyms COPS1; CSN1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [8]
3 Co-fractionation [11]
Interacting Protein Name COP9 signalosome complex subunit 3 (COPS3) Interacting Protein Interacting Protein Info
UniProt ID
CSN3_HUMAN 
Synonyms CSN3; SGN3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [8]
3 Co-fractionation [9]
Interacting Protein Name COP9 signalosome complex subunit 4 (COPS4) Interacting Protein Interacting Protein Info
UniProt ID
CSN4_HUMAN 
Synonyms CSN4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [8]
3 Co-fractionation [9]
Interacting Protein Name COP9 signalosome complex subunit 7a (COPS7A) Interacting Protein Interacting Protein Info
UniProt ID
CSN7A_HUMAN 
Synonyms CSN7; CSN7A; SGN7a
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [12]
3 Far Western [10]
Interacting Protein Name COP9 signalosome complex subunit 7b (COPS7B) Interacting Protein Interacting Protein Info
UniProt ID
CSN7B_HUMAN 
Synonyms CSN7B; SGN7b
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [8]
3 Co-fractionation [12]
Interacting Protein Name COP9 signalosome complex subunit 8 (COPS8) Interacting Protein Interacting Protein Info
UniProt ID
CSN8_HUMAN 
Synonyms COP9; CSN8; SGN8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [13]
Interacting Protein Name COP9 signalosome complex subunit 9 (COPS9) Interacting Protein Interacting Protein Info
UniProt ID
CSN9_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [14]
Cullins [+] 4 Cullins +
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [15]
3 Biochemical Activity [16]
Interacting Target Name Cullin-3 (CUL-3) Literature-reported Target Interacting Protein Info
UniProt ID
CUL3_HUMAN 
Synonyms KIAA0617; Cullin3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
Interacting Protein Name Cullin-2 (CUL2) Interacting Protein Interacting Protein Info
UniProt ID
CUL2_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Biochemical Activity [17]
Interacting Protein Name Cullin-4A (CUL4A) Interacting Protein Interacting Protein Info
UniProt ID
CUL4A_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Biochemical Activity [17]
Isomerases [+] 2 Isomerases +
Interacting Target Name Macrophage migration inhibitory factor (MIF) Clinical trial Target Interacting Protein Info
UniProt ID
MIF_HUMAN 
Synonyms Phenylpyruvate tautomerase; MMIF; L-dopachrome tautomerase; L-dopachrome isomerase; Glycosylation-inhibiting factor; GLIF; GIF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Affinity Capture-Western [19]
3 Reconstituted Complex [19]
4 Yeast two hybrid [18]
Interacting Target Name DNA topoisomerase II alpha (TOP2A) Clinical trial Target Interacting Protein Info
UniProt ID
TOP2A_HUMAN 
Synonyms TOP2; DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2-alpha; DNA topoisomerase 2alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Yeast two hybrid [21]
Kinases [+] 4 Kinases +
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Biochemical Activity [22]
3 Fluorescence Resonance Energy Transfer [22]
4 Yeast two hybrid [22]
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [11]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [22]
Interacting Target Name Endoplasmic reticulum to nucleus signaling 1 (ERN1) Clinical trial Target Interacting Protein Info
UniProt ID
ERN1_HUMAN 
Synonyms Serine/threonine-protein kinase/endoribonuclease IRE1; Ire1-alpha; IRE1a; IRE1; Inositol-requiring protein 1; hIRE1p; Endoplasmic reticulum-to-nucleus signaling 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Yeast two hybrid [24]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name FAD-linked sulfhydryl oxidase ALR (GFER) Interacting Protein Interacting Protein Info
UniProt ID
ALR_HUMAN 
Synonyms ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Reconstituted Complex [25]
Peptidases [+] 1 Peptidases +
Interacting Protein Name COP9 signalosome complex subunit 6 (COPS6) Interacting Protein Interacting Protein Info
UniProt ID
CSN6_HUMAN 
Synonyms CSN6; MOV34.34KD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-crystal Structure [16]
3 Co-fractionation [9]
4 Reconstituted Complex [26]
Pore-forming toxins [+] 2 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Far Western [28]
3 Reconstituted Complex [28]
Interacting Target Name Amyloid beta A4 protein (APP) Successful Target Interacting Protein Info
UniProt ID
A4_HUMAN 
Synonyms Vascular beta-amyloid; Protease nexin-II; PreA4; PN-II; CVAP; Cerebral vascular amyloidpeptide; Cerebral vascular amyloid peptide; Beta-amyloid peptide; APPI; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Amyloid precursor protein; Amyloid beta precursor protein; Alzheimer's disease amyloid protein; Alzheimer disease amyloid protein; AD1; ABPP; A4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Reconstituted Complex [30]
Transcription regulators [+] 4 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Co-localization [31]
3 Reconstituted Complex [32]
4 Yeast two hybrid [31]
Interacting Protein Name Mothers against decapentaplegic homolog 4 (SMAD4) Interacting Protein Interacting Protein Info
UniProt ID
SMAD4_HUMAN 
Synonyms DPC4; JIP; MADH4; MYHRS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Reconstituted Complex [34]
3 Yeast two hybrid [33]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [36]
Interacting Target Name DNA-binding factor KBF1 (p105) Clinical trial Target Interacting Protein Info
UniProt ID
NFKB1_HUMAN 
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NFkappaB p105 subunit; EBP-1; EBP1; DNA-binding factor KBF1; DNAbinding factor KBF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [37]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-like protein Nedd8 (NEDD8) Clinical trial Target Interacting Protein Info
UniProt ID
NEDD8_HUMAN 
Synonyms Ubiquitin-like protein Nedd8; Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [16]
Other proteins [+] 3 Other proteins +
Interacting Target Name Thioredoxin (TXN) Clinical trial Target Interacting Protein Info
UniProt ID
THIO_HUMAN 
Synonyms TRX1; Trx; TRDX; Surface-associated sulphydryl protein; Surface associated sulphydryl protein; SASP; ATL-derived factor; ADF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [38]
3 Fluorescence Resonance Energy Transfer [38]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Reconstituted Complex [40]
Interacting Protein Name Cullin-associated NEDD8-dissociated protein 1 (CAND1) Interacting Protein Interacting Protein Info
UniProt ID
CAND1_HUMAN 
Synonyms TIP120; TIP120A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [41]
References  Top
REF 1 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 2 COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP. J Biol Chem. 2009 Dec 11;284(50):34944-53.
REF 3 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 4 Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 2008 Sep;7(9):3879-89.
REF 5 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 6 DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev. 2006 Nov 1;20(21):2949-54.
REF 7 Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival. PLoS One. 2013;8(3):e60000.
REF 8 Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem. 2006 Jun 23;281(25):17457-65.
REF 9 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 10 Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. J Mol Biol. 2000 Jul 28;300(5):1169-78.
REF 11 CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation. J Biol Chem. 2013 Sep 20;288(38):27208-19.
REF 12 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 13 Endothelial CSN5 impairs NF-B activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thromb Haemost. 2013 Jul;110(1):141-52.
REF 14 Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. PLoS One. 2013 Jun 12;8(6):e65285.
REF 15 CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Biochem Biophys Res Commun. 2005 Sep 2;334(3):867-74.
REF 16 Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. PLoS One. 2014 Aug 21;9(8):e105688.
REF 17 The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One. 2012;7(8):e43980.
REF 18 Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif. FEBS Lett. 2005 Mar 14;579(7):1693-701.
REF 19 Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature. 2000 Nov 9;408(6809):211-6.
REF 20 Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase II degradation in hepatocellular carcinoma cells. Hepatology. 2011 Jan;53(1):148-59.
REF 21 Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. J Biol Chem. 2004 Jul 23;279(30):31296-303.
REF 22 Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome. J Cell Mol Med. 2010 Jun;14(6B):1555-68.
REF 23 Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Mol Cancer Res. 2007 Oct;5(10):1063-72.
REF 24 JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Neurochem Int. 2004 Oct;45(5):765-72.
REF 25 Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. FASEB J. 2002 Jan;16(1):90-2.
REF 26 Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009 Jan 14;17(1):31-40.
REF 27 Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 2008 Mar 1;103(4):1219-30.
REF 28 COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 2001 Apr 2;20(7):1630-9.
REF 29 COPS5 (Jab1) protein increases site processing of amyloid precursor protein and amyloid peptide generation by stabilizing RanBP9 protein levels. J Biol Chem. 2013 Sep 13;288(37):26668-77.
REF 30 Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem. 2011 Sep 30;286(39):34088-100.
REF 31 A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 1996 Oct 3;383(6599):453-7.
REF 32 Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature. 2000 Apr 6;404(6778):617-21.
REF 33 Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep. 2002 Feb;3(2):171-6.
REF 34 Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1. Mol Cell Biochem. 2014 Jan;385(1-2):145-57.
REF 35 HIF1-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. PLoS One. 2015 Sep 9;10(9):e0137513.
REF 36 Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 2004 Apr 1;18(7):739-44.
REF 37 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 38 Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. Oncogene. 2004 Nov 25;23(55):8868-75.
REF 39 Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). Oncogene. 2002 May 2;21(19):3003-10.
REF 40 Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Res. 2006 Sep 1;66(17):8581-9.
REF 41 Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20.

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