Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Mothers against decapentaplegic homolog 4 (SMAD4) | ||||
| UniProt ID | SMAD4_HUMAN | ||||
| Gene Name | SMAD4 | ||||
| Gene ID | 4089 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Transcription factor Sp1 (SP1) | Target Info | PPI Info | [2] | |
| Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | JUN activation domain binding protein (COPS5) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature. 2002 Aug 8;418(6898):641-6. | ||||
| REF 2 | Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. Biochem J. 2008 May 15;412(1):123-30. | ||||
| REF 3 | A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Genes Dev. 2000 Jul 1;14(13):1605-16. | ||||
| REF 4 | Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep. 2002 Feb;3(2):171-6. | ||||
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