Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T99340 Target Info
Target Name Receptor-interacting protein 1 (RIPK1)
Synonyms Receptor-interacting serine/threonine-protein kinase 1; RIP1; RIP-1; RIP; Cell death protein RIP
Target Type Clinical trial Target
Gene Name RIPK1
Biochemical Class Kinase
UniProt ID
RIPK1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Biochemical Activity [5]
6 Reconstituted Complex [6]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Affinity Capture-Western [11]
6 Yeast two hybrid [12]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [13]
3 Reconstituted Complex [13]
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [14]
Interacting Protein Name E3 ubiquitin-protein ligase RNF216 (RNF216) Interacting Protein Interacting Protein Info
UniProt ID
RN216_HUMAN 
Synonyms CAHH; TRIAD3; U7I1; UBCE7IP1; ZIN
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Yeast two hybrid [16]
Adapter proteins [+] 3 Adapter proteins +
Interacting Protein Name FAS-associated death domain protein (FADD) Interacting Protein Interacting Protein Info
UniProt ID
FADD_HUMAN 
Synonyms MORT1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [19]
4 Affinity Capture-Western [20]
5 Affinity Capture-Western [21]
6 Reconstituted Complex [22]
7 Yeast two hybrid [16]
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) Interacting Protein Interacting Protein Info
UniProt ID
TAB2_HUMAN 
Synonyms CHTD2; MAP3K7IP2; TAB.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [23]
3 Affinity Capture-Western [24]
Interacting Protein Name TNF receptor-associated factor 5 (TRAF5) Interacting Protein Interacting Protein Info
UniProt ID
TRAF5_HUMAN 
Synonyms MGC:39780; RNF84
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [25]
Kinases [+] 2 Kinases +
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [27]
4 Affinity Capture-Western [10]
5 Co-fractionation [27]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [27]
2 Reconstituted Complex [28]
Peptidases [+] 2 Peptidases +
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [19]
4 Affinity Capture-Western [20]
5 Affinity Capture-Western [21]
6 Co-fractionation [29]
7 Co-localization [19]
8 Reconstituted Complex [22]
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Preclinical Target Interacting Protein Info
UniProt ID
UBP2_HUMAN 
Synonyms UBP41; Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
Other proteins [+] 3 Other proteins +
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Affinity Capture-Western [33]
3 Affinity Capture-Western [26]
4 Affinity Capture-Western [34]
5 Co-fractionation [27]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [35]
2 Affinity Capture-Western [36]
3 Reconstituted Complex [37]
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [38]
2 Affinity Capture-Western [39]
References  Top
REF 1 Parkin regulates NF-B by mediating site-specific ubiquitination of RIPK1. Cell Death Dis. 2018 Jun 28;9(7):732.
REF 2 Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3. Cell Signal. 2016 Feb;28(2):72-80.
REF 3 cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008 Jun 20;30(6):689-700.
REF 4 PPAR Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers. Mol Cancer Ther. 2017 Nov;16(11):2528-2542.
REF 5 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23;36(2):302-14.
REF 6 c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
REF 7 X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability. FEBS Lett. 2016 Dec;590(23):4381-4392.
REF 8 TRAF2 is a biologically important necroptosis suppressor. Cell Death Differ. 2015 Nov;22(11):1846-57.
REF 9 The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J Cell Biol. 2011 Feb 7;192(3):391-9.
REF 10 TRIM38 inhibits TNF- and IL-1-triggered NF-B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1509-14.
REF 11 TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity. 1996 Apr;4(4):387-96.
REF 12 MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 1997 Feb 6;385(6616):540-4.
REF 13 cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356.
REF 14 De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 2004 Aug 5;430(7000):694-9.
REF 15 Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. J Biol Chem. 2006 Nov 10;281(45):34592-600.
REF 16 A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. J Biol Chem. 2002 May 3;277(18):15985-91.
REF 17 NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ. 2009 Sep;16(9):1279-88.
REF 18 NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF- feedforward signaling. Cell. 2011 Apr 1;145(1):92-103.
REF 19 The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Cell Death Dis. 2014 Feb 27;5:e1085.
REF 20 FADD regulates NF-B activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016 Mar 14;6:22787.
REF 21 MiR-145 promotes TNF--induced apoptosis by facilitating the formation of RIP1-FADDcaspase-8 complex in triple-negative breast cancer. Tumour Biol. 2016 Jul;37(7):8599-607.
REF 22 The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell. 2011 Aug 5;43(3):432-48.
REF 23 NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Cell Signal. 2008 Jun;20(6):1044-51.
REF 24 TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004 Aug 27;15(4):535-48.
REF 25 Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem. 2001 Sep 28;276(39):36530-4.
REF 26 Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem. 2006 May 12;281(19):13636-43.
REF 27 A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol. 2011 Jul;31(14):2774-86.
REF 28 Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem. 2000 Dec 1;275(48):37966-77.
REF 29 A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov. 2012 Feb;2(2):140-55.
REF 30 De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65.
REF 31 De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Cell Death Differ. 2012 May;19(5):891-9.
REF 32 An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 2000 Sep 8;275(36):27823-31.
REF 33 Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-B activation and leads to incontinentia pigmenti. J Allergy Clin Immunol. 2017 Dec;140(6):1671-1682.e2.
REF 34 Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. J Biol Chem. 2001 Jun 1;276(22):19012-9.
REF 35 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
REF 36 Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 2003 May;18(5):655-64.
REF 37 Sam68 is required for both NF-B activation and apoptosis signaling by the TNF receptor. Mol Cell. 2011 Jul 22;43(2):167-79.
REF 38 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 39 RAIDD is a new 'death' adaptor molecule. Nature. 1997 Jan 2;385(6611):86-9.

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