Target Information

Target General Infomation
Target ID
T11487
Former ID
TTDC00313
Target Name
Acetyl-CoA acetyltransferase, mitochondrial
Gene Name
ACAT1
Synonyms
Acetoacetyl-CoA thiolase; T2; ACAT1
Target Type
Discontinued
Disease Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25]
Function
Plays a major role in ketone body metabolism.
BioChemical Class
Acyltransferase
Target Validation
T11487
UniProt ID
P24752
EC Number
EC 2.3.1.9
Sequence
MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLS
LLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCT
TINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIV
KDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTV
TVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADA
AKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVV
LANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGAS
AMLIQKL
Drugs and Mode of Action
Drug(s) Benoxaprofen Drug Info Withdrawn from market Inflammatory disease [533566]
Inhibitor (Z)-2,6-diisopropyl-N-phenyloctadec-9-enamide Drug Info [529319]
Benoxaprofen Drug Info [537712]
compound 15a Drug Info [527814]
compound 15b Drug Info [527814]
compound 16 Drug Info [527814]
compound 18a Drug Info [527814]
compound 18b Drug Info [527814]
compound 22c Drug Info [527814]
compound 22d Drug Info [527814]
compound 26a Drug Info [527814]
compound 26b Drug Info [527814]
compound 26c Drug Info [527814]
Nonanoic acid biphenyl-2-ylamide Drug Info [529319]
Octanoic acid biphenyl-2-ylamide Drug Info [529319]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Isoleucine degradation
Glutaryl-CoA degradation
Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
Ketogenesis
Ketolysis
KEGG Pathway Fatty acid degradation
Synthesis and degradation of ketone bodies
Valine, leucine and isoleucine degradation
Lysine degradation
Tryptophan metabolism
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
Propanoate metabolism
Butanoate metabolism
Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Fatty acid metabolism
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Butyrate Metabolism
Fatty acid Metabolism
Ketone Body Metabolism
Lysine Degradation
Valine, Leucine and Isoleucine Degradation
Pyruvate Metabolism
Propanoate Metabolism
Circadian clock
WikiPathways Tryptophan metabolism
Synthesis and Degradation of Ketone Bodies
Metabolism of amino acids and derivatives
Fatty acid, triacylglycerol, and ketone body metabolism
Fatty Acid Beta Oxidation
References
Ref 533566Benoxaprofen: side-effect profile in 300 patients. Br Med J (Clin Res Ed). 1982 May 8;284(6326):1365-8.
Ref 527814Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. Epub 2005 Oct 18.Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility.
Ref 529319J Med Chem. 2008 Mar 13;51(5):1474-7. Epub 2008 Feb 20.Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors.
Ref 537712Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. Prostaglandins. 1988 Jun;35(6):939-44.

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