Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Protein kinase C zeta (PRKCZ) | Patented-recorded | Target Info | ||
UniProt ID | KPCZ_HUMAN | ||||
Gene Name | PRKCZ | ||||
Gene ID | 5590 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [2] | ||
RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [3] | ||
RAC-gamma serine/threonine-protein kinase (AKT3) | Target Info | PPI Info | [4] | ||
Interacting Clinical trial Target(s) | Phosphoinositide dependent protein kinase-1 (PDPK1) | Target Info | PPI Info | [5] | |
Nucleophosmin (NPM1) | Target Info | PPI Info | [2] | ||
Transcription factor Sp1 (SP1) | Target Info | PPI Info | [6] | ||
Interacting Patented-recorded Target(s) | Protein kinase C zeta (PRKCZ) | Target Info | PPI Info | [2] | |
Interacting Literature-reported Target(s) | Sequestosome-1 p62 (SQSTM1) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | Profiling the interactome of protein kinase C by proteomics and bioinformatics. Proteome Sci. 2018 Feb 26;16:5. | ||||
REF 3 | Protein kinase Czeta is a negative regulator of protein kinase B activity. J Biol Chem. 1999 Mar 26;274(13):8589-96. | ||||
REF 4 | Characterization of PDK2 activity against protein kinase B gamma. Biochemistry. 2002 Aug 13;41(32):10351-9. | ||||
REF 5 | Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. Biochemistry. 2002 Jan 15;41(2):561-9. | ||||
REF 6 | Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. Mol Cell Biol. 2006 Sep;26(18):6748-61. | ||||
REF 7 | The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000 Apr 3;19(7):1576-86. |
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