Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T55610 Target Info
Target Name Hypoxia-inducible factor 1 alpha (HIF-1A)
Synonyms bHLHe78; Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; Member of PAS protein 1; MOP1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1 A; Hypoxia inducible factor 1; HIF1-alpha; HIF1 alpha; HIF-1alpha; HIF-1-alpha; HIF-1 alpha; Class E basic helix-loop-helix protein 78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Target Type Clinical trial Target
Gene Name HIF1A
UniProt ID
HIF1A_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name RuvB-like 2 (RUVBL2) Interacting Protein Interacting Protein Info
UniProt ID
RUVB2_HUMAN 
Synonyms ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Fluorescence Resonance Energy Transfer [1]
Interacting Target Name DNA replication licensing factor MCM7 (MCM7) Literature-reported Target Interacting Protein Info
UniProt ID
MCM7_HUMAN 
Synonyms P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [3]
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [5]
4 Yeast two hybrid [6]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-localization [8]
3 Reconstituted Complex [7]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [9]
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
Interacting Target Name Transcription intermediary factor 1-beta (TRIM28) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1B_HUMAN 
Synonyms Tripartite motif-containing protein 28; TIF1-beta; TIF1B; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP-1; KAP1; E3 SUMO-protein ligase TRIM28
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [13]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Receptor of activated protein C kinase 1 (RACK1) Literature-reported Target Interacting Protein Info
UniProt ID
RACK1_HUMAN 
Synonyms Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [14]
Carbon-nitrogen hydrolases [+] 5 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [15]
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [16]
2 Reconstituted Complex [17]
Interacting Target Name Histone deacetylase 4 (HDAC4) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC4_HUMAN 
Synonyms KIAA0288; HD4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Yeast two hybrid [19]
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [11]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [15]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Fluorescence Resonance Energy Transfer [22]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-2 (CUL2) Interacting Protein Interacting Protein Info
UniProt ID
CUL2_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [23]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Extracellular calcium-sensing receptor (CASR) Successful Target Interacting Protein Info
UniProt ID
CASR_HUMAN 
Synonyms PCaR1; Parathyroid cell calcium-sensing receptor 1; Parathyroid Cell calcium-sensing receptor; Parathyroid cell calciumreceptor; Parathyroid calcium receptor; hCasR; GPRC2A; CaSR; CaR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Reconstituted Complex [25]
Heat shock proteins [+] 3 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [26]
3 Reconstituted Complex [27]
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Reconstituted Complex [29]
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Reconstituted Complex [29]
Kinases [+] 2 Kinases +
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Co-localization [32]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [33]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [34]
2 Affinity Capture-Western [35]
Oxidoreductases [+] 5 Oxidoreductases +
Interacting Target Name Quinone reductase 1 (NQO1) Clinical trial Target Interacting Protein Info
UniProt ID
NQO1_HUMAN 
Synonyms Qui reductase 1; QR1; Phylloquinone reductase; Phylloqui reductase; NMOR1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H dehydrogenase [quinone] 1; Menadione reductase; DT-diaphorase 1; DT-diaphorase; DTD; DIA4; Azoreductase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [36]
3 Reconstituted Complex [36]
Interacting Target Name HIF-prolyl hydroxylase 2 (HPH-2) Patented-recorded Target Interacting Protein Info
UniProt ID
EGLN1_HUMAN 
Synonyms SM-20; SM20; Prolyl hydroxylase domain-containing protein 2; Prolyl hydroxylase domaincontaining protein 2; PNAS-137; PNAS-118; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; Hypoxiainducible factor prolyl hydroxylase 2; HPH2; HIFprolyl hydroxylase 2; HIF-PH2; HIFPH2; Egl nine homolog 1; C1orf12
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Fluorescence Resonance Energy Transfer [38]
3 Reconstituted Complex [39]
Interacting Protein Name Egl nine homolog 3 (EGLN3) Interacting Protein Interacting Protein Info
UniProt ID
EGLN3_HUMAN 
Synonyms HIFP4H3; HIFPH3; PHD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Reconstituted Complex [41]
3 Yeast two hybrid [42]
Interacting Protein Name Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) Interacting Protein Interacting Protein Info
UniProt ID
HIF1N_HUMAN 
Synonyms FIH1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [43]
3 Reconstituted Complex [44]
Interacting Target Name HIF-prolyl hydroxylase 1 (HPH-1) Successful Target Interacting Protein Info
UniProt ID
EGLN2_HUMAN 
Synonyms Prolyl hydroxylase domain-containing protein 1; PHD1; Hypoxia-inducible factor prolyl hydroxylase 1; HPH-3; HIF-PH1; HIF-PH; Estrogen-induced tag6; Estrogen-induced tag 6; EIT-6; EIT6; Egl nine homolog 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Reconstituted Complex [41]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Reconstituted Complex [47]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Reconstituted Complex [49]
Transcription regulators [+] 7 Transcription regulators +
Interacting Protein Name Aryl hydrocarbon receptor nuclear translocator (ARNT) Interacting Protein Interacting Protein Info
UniProt ID
ARNT_HUMAN 
Synonyms HIF.1.beta; HIF.1beta; HIF1.beta; HIF1B; HIF1BETA; TANGO; bHLHe2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [50]
2 Affinity Capture-Western [51]
3 Co-fractionation [52]
4 Co-localization [31]
5 Fluorescence Resonance Energy Transfer [53]
6 Reconstituted Complex [53]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [54]
2 Affinity Capture-Western [55]
3 Co-localization [55]
4 Reconstituted Complex [55]
5 Yeast two hybrid [54]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Co-crystal Structure [57]
3 Fluorescence Resonance Energy Transfer [58]
4 Reconstituted Complex [59]
5 Yeast two hybrid [59]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [60]
2 Affinity Capture-Western [61]
3 Co-localization [62]
4 Reconstituted Complex [61]
Interacting Protein Name CCAAT/enhancer-binding protein alpha (CEBPA) Interacting Protein Interacting Protein Info
UniProt ID
CEBPA_HUMAN 
Synonyms C/EBP.alpha; CEBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Co-localization [64]
3 Reconstituted Complex [63]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [65]
2 Fluorescence Resonance Energy Transfer [22]
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Reconstituted Complex [67]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Reconstituted Complex [68]
3 Yeast two hybrid [69]
Other proteins [+] 4 Other proteins +
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [50]
2 Affinity Capture-Western [70]
3 Protein-Fragment Complementation Assay [71]
4 Protein-peptide [72]
5 Reconstituted Complex [73]
Interacting Protein Name Elongin-B (ELOB) Interacting Protein Interacting Protein Info
UniProt ID
ELOB_HUMAN 
Synonyms ELOB; SIII
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [23]
Interacting Protein Name Elongin-C (ELOC) Interacting Protein Interacting Protein Info
UniProt ID
ELOC_HUMAN 
Synonyms SIII; eloC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [3]
Interacting Protein Name Four and a half LIM domains protein 2 (FHL2) Interacting Protein Interacting Protein Info
UniProt ID
FHL2_HUMAN 
Synonyms AAG11; DRAL; FHL.2; SLIM.3; SLIM3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [74]
2 Reconstituted Complex [74]
References  Top
REF 1 The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 Jun 28;16(1):37-47.
REF 2 Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell. 2010 Jul 9;39(1):71-85.
REF 3 MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011 Jun 10;42(5):700-12.
REF 4 HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 2013 Jun 6;153(6):1327-39.
REF 5 Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex. J Am Chem Soc. 2013 Mar 20;135(11):4537-49.
REF 6 Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 2004 Jul;6(1):33-43.
REF 7 TRAF6 upregulates expression of HIF-1 and promotes tumor angiogenesis. Cancer Res. 2013 Aug 1;73(15):4950-9.
REF 8 A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1 activation, tumorigenesis andmetastasis. Nat Cell Biol. 2017 Jan;19(1):38-51.
REF 9 Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem. 2010 Feb 5;285(6):3651-63.
REF 10 Functional regulation of hypoxia inducible factor-1 by SET9 lysine methyltransferase. Biochim Biophys Acta. 2015 May;1853(5):881-91.
REF 11 Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell. 2010 Jun 25;38(6):864-78.
REF 12 HIF1 protein stability is increased by acetylation at lysine 709. J Biol Chem. 2012 Oct 12;287(42):35496-505.
REF 13 A unique SUMO-2-interacting motif within LANA is essential for KSHV latency. PLoS Pathog. 2013;9(11):e1003750.
REF 14 Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007 Nov 16;282(46):33358-66.
REF 15 Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep. 2007 Mar;17(3):647-51.
REF 16 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 17 FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001 Oct 15;15(20):2675-86.
REF 18 Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 2009 Jan 5;583(1):55-60.
REF 19 Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem. 2004 Oct 1;279(40):41966-74.
REF 20 Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1 protein under hypoxic conditions. PLoS One. 2012;7(3):e33433.
REF 21 The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription. J Biol Chem. 2001 Jul 27;276(30):28421-9.
REF 22 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 23 NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. EMBO Rep. 2008 May;9(5):486-91.
REF 24 Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha. FEBS J. 2009 Jul;276(13):3470-80.
REF 25 von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase. Int J Biochem Cell Biol. 2011 May;43(5):795-804.
REF 26 Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2006 Mar;26(6):2019-28.
REF 27 PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem. 2004 Apr 2;279(14):13506-13.
REF 28 Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res. 2006 Sep 1;66(17):8814-21.
REF 29 MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei. FEBS Lett. 2008 Jul 9;582(16):2357-64.
REF 30 COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. PLoS One. 2009 Oct 5;4(10):e7332.
REF 31 Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci. 2005 Jan 15;118(Pt 2):301-11.
REF 32 HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005 Apr 28;24(19):3110-20.
REF 33 Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1 to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3325-34.
REF 34 Identification of proteins associated with ligand-activated estrogen receptor in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Proteomics. 2011 Jan;11(1):172-9.
REF 35 Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells. Mol Endocrinol. 2005 May;19(5):1191-9.
REF 36 NQO1 inhibits proteasome-mediated degradation of HIF-1. Nat Commun. 2016 Dec 14;7:13593.
REF 37 Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1. PLoS One. 2015 May 14;10(5):e0123725.
REF 38 Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling. J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76.
REF 39 A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):654-9.
REF 40 HEXIM1 down-regulates hypoxia-inducible factor-1 protein stability. Biochem J. 2013 Dec 1;456(2):195-204.
REF 41 The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol. 2007 May;27(10):3758-68.
REF 42 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 43 A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. Mol Cancer Ther. 2008 Dec;7(12):3729-38.
REF 44 Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40.
REF 45 CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016 Jan 1;129(1):191-205.
REF 46 HIF1-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. PLoS One. 2015 Sep 9;10(9):e0137513.
REF 47 Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 2004 Apr 1;18(7):739-44.
REF 48 Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem. 2003 Apr 18;278(16):13595-8.
REF 49 Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10305-9.
REF 50 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 51 COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest. 2010 Jun;120(6):2119-30.
REF 52 Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. J Cell Sci. 1999 Apr;112 ( Pt 8):1203-12.
REF 53 A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135(28):10418-25.
REF 54 A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J Mol Biol. 2004 Feb 6;336(1):9-24.
REF 55 Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001 Oct 19;276(42):38527-35.
REF 56 K63-polyubiquitinated HAUSP deubiquitinates HIF-1 and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. Nat Commun. 2016 Dec 9;7:13644.
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