Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T64205 Target Info
Target Name Signal transducer and activator of transcription 1 (STAT1)
Synonyms Transcription factor ISGF-3 components p91/p84; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; STAT-1; P91
Target Type Patented-recorded Target
Gene Name STAT1
Biochemical Class Transcription factor
UniProt ID
STAT1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name DNA replication licensing factor MCM5 (MCM5) Interacting Protein Interacting Protein Info
UniProt ID
MCM5_HUMAN 
Synonyms CDC46; P1.CDC46
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 SUMO-protein ligase PIAS1 (PIAS1) Interacting Protein Interacting Protein Info
UniProt ID
PIAS1_HUMAN 
Synonyms DDXBP1; GBP; GU/RH.II; ZMIZ3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Co-localization [6]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-localization [8]
Kinases [+] 7 Kinases +
Interacting Target Name Protein kinase C delta (PRKCD) Clinical trial Target Interacting Protein Info
UniProt ID
KPCD_HUMAN 
Synonyms Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; Protein Kinase C delta; PKC-delta; nPKC-delta
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [12]
5 Biochemical Activity [13]
6 Co-fractionation [12]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [14]
2 Affinity Capture-MS [15]
3 Affinity Capture-Western [16]
4 Protein-Fragment Complementation Assay [14]
5 Yeast two hybrid [17]
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [12]
3 Co-fractionation [12]
4 Co-localization [6]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [19]
3 Co-localization [6]
4 Reconstituted Complex [18]
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Affinity Capture-Western [21]
3 Co-localization [22]
Interacting Target Name Tyrosine-protein kinase Kit (KIT) Successful Target Interacting Protein Info
UniProt ID
KIT_HUMAN 
Synonyms v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; p145 c-kit; Mast/stem cell growth factor receptor Kit; C-kit; CD117 antigen; CD117
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Co-localization [6]
3 Reconstituted Complex [23]
Interacting Target Name Tyrosine-protein kinase EIF2AK2 (p68) Patented-recorded Target Interacting Protein Info
UniProt ID
E2AK2_HUMAN 
Synonyms Proteinkinase RNA-activated; Protein kinase RNA-activated; Protein kinase R; PRKR; PKR; p68 kinase; P1/eIF-2A protein kinase; Interferon-inducible RNA-dependent protein kinase; Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Reconstituted Complex [25]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name Exportin-1 (XPO1) Clinical trial Target Interacting Protein Info
UniProt ID
XPO1_HUMAN 
Synonyms Exp1; CRM1; Chromosome region maintenance 1 protein homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Protein-peptide [27]
Transcription regulators [+] 4 Transcription regulators +
Interacting Protein Name Signal transducer and activator of transcription 2 (STAT2) Interacting Protein Interacting Protein Info
UniProt ID
STAT2_HUMAN 
Synonyms ISGF.3; P113; STAT113
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [30]
4 Affinity Capture-Western [31]
5 Affinity Capture-Western [32]
6 Co-localization [29]
7 Co-purification [33]
8 Reconstituted Complex [34]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Affinity Capture-Western [35]
3 Co-localization [6]
4 Reconstituted Complex [36]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Biochemical Activity [38]
3 Reconstituted Complex [39]
4 Reconstituted Complex [40]
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [41]
2 Co-fractionation [42]
References  Top
REF 1 Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3034-9.
REF 2 Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. 1998 Dec 1;17(23):6963-71.
REF 3 TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. J Immunol. 2007 Apr 1;178(7):4284-95.
REF 4 Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001 Mar 9;104(5):731-41.
REF 5 Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem. 2002 Sep 27;277(39):35787-90.
REF 6 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 7 Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol. 2009 Dec 1;183(11):6981-8.
REF 8 Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)- in CD36 Protein Expression and Foam Cell Formation. J Biol Chem. 2015 Dec 18;290(51):30306-20.
REF 9 Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J Biol Chem. 2003 Sep 5;278(36):33637-44.
REF 10 Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem. 2002 Apr 26;277(17):14408-16.
REF 11 Protein kinase Cdelta regulates apoptosis via activation of STAT1. J Biol Chem. 2004 Oct 29;279(44):45603-12.
REF 12 Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion. J Biol Chem. 2009 Sep 4;284(36):24341-53.
REF 13 Activation of protein kinase C delta by IFN-gamma. J Immunol. 2003 Jul 1;171(1):267-73.
REF 14 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 15 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul;13(7):1644-58.
REF 16 ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem. 1999 Jun 11;274(24):17209-18.
REF 17 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 18 Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J Biol Chem. 2001 Jun 1;276(22):19512-23.
REF 19 Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium. Reprod Biol Endocrinol. 2010 Jun 24;8:74.
REF 20 Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cell Signal. 2010 Aug;22(8):1206-13.
REF 21 Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1. Mol Pharmacol. 2004 Mar;65(3):589-98.
REF 22 Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):105-12.
REF 23 Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem J. 1997 Oct 1;327 ( Pt 1):73-80.
REF 24 Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. 1997 Mar 17;16(6):1291-304.
REF 25 Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR. J Biol Chem. 2001 Apr 27;276(17):13727-37.
REF 26 A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife. 2015 Dec 17;4. pii: e11466.
REF 27 Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell. 2012 Sep;23(18):3677-93.
REF 28 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 29 Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J Biol Chem. 1999 Aug 20;274(34):24059-65.
REF 30 Acetylation-dependent signal transduction for type I interferon receptor. Cell. 2007 Oct 5;131(1):93-105.
REF 31 IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J Immunol. 1999 Oct 1;163(7):3834-41.
REF 32 Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626-31.
REF 33 Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J Biol Chem. 1996 Mar 8;271(10):5790-4.
REF 34 Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J Biol Chem. 2002 Aug 16;277(33):30072-8.
REF 35 Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur J Haematol. 2001 Aug;67(2):63-71.
REF 36 PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. 2005 Nov 10;24(49):7290-300.
REF 37 Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1074-9.
REF 38 Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev. 2006 Feb 15;20(4):473-85.
REF 39 The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J Biol Chem. 2005 Apr 15;280(15):14989-96.
REF 40 The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb. J Mol Biol. 2014 Dec 12;426(24):4030-4048.
REF 41 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 42 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.

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