Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T51191 Target Info
Target Name Histone deacetylase 2 (HDAC2)
Synonyms HD2
Target Type Clinical trial Target
Gene Name HDAC2
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
HDAC2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name Chromodomain-helicase-DNA-binding protein 4 (CHD4) Interacting Protein Interacting Protein Info
UniProt ID
CHD4_HUMAN 
Synonyms CHD.4; Mi.2b; Mi2.BETA
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-MS [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [4]
8 Affinity Capture-Western [5]
Interacting Protein Name Chromodomain-helicase-DNA-binding protein 3 (CHD3) Interacting Protein Interacting Protein Info
UniProt ID
CHD3_HUMAN 
Synonyms Mi.2a; Mi2.ALPHA; ZFH
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [4]
6 Co-purification [7]
Interacting Target Name Mitotic growth and transcription activator (BAF190A) Literature-reported Target Interacting Protein Info
UniProt ID
SMCA4_HUMAN 
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2-beta; SNF2B; Protein BRG-1; Protein brahma homolog 1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [9]
3 Co-purification [10]
Interacting Protein Name Sucrose nonfermenting protein 2 homolog (SMARCA5) Interacting Protein Interacting Protein Info
UniProt ID
SMCA5_HUMAN 
Synonyms ISWI; SNF2H; WCRF135; hISWI; hSNF2H
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-fractionation [12]
3 Co-purification [7]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name MHC class II transactivator (CIITA) Interacting Protein Interacting Protein Info
UniProt ID
C2TA_HUMAN 
Synonyms C2TA; CIITAIV; MHC2TA; NLRA
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [13]
2 Reconstituted Complex [14]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name Histone-binding protein RBBP4 (RBBP4) Interacting Protein Interacting Protein Info
UniProt ID
RBBP4_HUMAN 
Synonyms NURF55; RBAP48; lin.53
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [5]
5 Affinity Capture-Western [15]
6 Affinity Capture-Western [16]
7 Affinity Capture-Western [4]
8 Co-fractionation [12]
Interacting Protein Name Histone-binding protein RBBP7 (RBBP7) Interacting Protein Interacting Protein Info
UniProt ID
RBBP7_HUMAN 
Synonyms RbAp46
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [15]
5 Co-fractionation [12]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 16 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [5]
5 Affinity Capture-Western [17]
6 Affinity Capture-Western [18]
7 Affinity Capture-Western [19]
8 Affinity Capture-Western [5]
9 Affinity Capture-Western [20]
10 Affinity Capture-Western [21]
11 Affinity Capture-Western [22]
12 Affinity Capture-Western [23]
13 Affinity Capture-Western [24]
14 Affinity Capture-Western [25]
15 Affinity Capture-Western [15]
16 Co-localization [26]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Reconstituted Complex [28]
Kinases [+] 1 Kinases +
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Biochemical Activity [29]
3 Co-fractionation [30]
Lyases [+] 1 Lyases +
Interacting Protein Name Chromodomain Y-like protein (CDYL) Interacting Protein Interacting Protein Info
UniProt ID
CDYL_HUMAN 
Synonyms CDYL1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [31]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Peroxisome proliferator-activated receptor delta (PPARD) Clinical trial Target Interacting Protein Info
UniProt ID
PPARD_HUMAN 
Synonyms PPAR-delta; PPARdelta; PPAR-beta; PPARB; Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Co-localization [26]
One-carbon transferases [+] 3 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Interacting Protein Info
UniProt ID
DNMT1_HUMAN 
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Affinity Capture-Western [34]
3 Reconstituted Complex [35]
Interacting Target Name DNA [cytosine-5]-methyltransferase 3B (DNMT3B) Clinical trial Target Interacting Protein Info
UniProt ID
DNM3B_HUMAN 
Synonyms M.HsaIIIB; Dnmt3b; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [36]
Interacting Target Name Enhancer of zeste homolog 2 (EZH2) Successful Target Interacting Protein Info
UniProt ID
EZH2_HUMAN 
Synonyms Lysine N-methyltransferase 6; Lysine Nmethyltransferase 6; KMT6; Histone-lysine N-methyltransferase EZH2; Histonelysine Nmethyltransferase EZH2; EZH2 Y641N mutations; EZH2 Y641F mutations; ENX-1; ENX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Co-fractionation [30]
Oxidoreductases [+] 2 Oxidoreductases +
Interacting Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target Interacting Protein Info
UniProt ID
KDM1A_HUMAN 
Synonyms Lysine-specific histone demethylase 1A; Lysinespecific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; Flavincontaining amine oxidase domaincontaining protein 2; BRAF35-HDAC complex protein BHC110; BRAF35HDAC complex protein BHC110; AOF2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [5]
5 Affinity Capture-Western [38]
6 Co-purification [39]
Interacting Protein Name C-terminal-binding protein 1 (CTBP1) Interacting Protein Interacting Protein Info
UniProt ID
CTBP1_HUMAN 
Synonyms BARS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Reconstituted Complex [41]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Reconstituted Complex [43]
Transcription regulators [+] 21 Transcription regulators +
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [44]
6 Affinity Capture-Western [4]
7 Co-fractionation [30]
8 Co-localization [45]
9 Reconstituted Complex [44]
Interacting Protein Name Methyl-CpG-binding domain protein 3 (MBD3) Interacting Protein Interacting Protein Info
UniProt ID
MBD3_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [15]
4 Affinity Capture-Western [22]
5 Co-fractionation [12]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Affinity Capture-Western [47]
3 Affinity Capture-Western [48]
4 Affinity Capture-Western [15]
5 Co-localization [26]
Interacting Protein Name SMARCE1-related protein (HMG20B) Interacting Protein Interacting Protein Info
UniProt ID
HM20B_HUMAN 
Synonyms BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [39]
Interacting Protein Name REST corepressor 1 (RCOR1) Interacting Protein Interacting Protein Info
UniProt ID
RCOR1_HUMAN 
Synonyms COREST; RCOR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [49]
4 Affinity Capture-Western [38]
Interacting Protein Name B-cell lymphoma/leukemia 11B (BCL11B) Interacting Protein Interacting Protein Info
UniProt ID
BC11B_HUMAN 
Synonyms ATL1; ATL1.alpha; ATL1.beta; ATL1.delta; ATL1.gamma; CTIP.2; CTIP2; RIT1; ZNF856B; hRIT1.alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [50]
3 Reconstituted Complex [50]
Interacting Protein Name Breast cancer metastasis-suppressor 1 (BRMS1) Interacting Protein Interacting Protein Info
UniProt ID
BRMS1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [51]
Interacting Protein Name General transcription factor II-I (GTF2I) Interacting Protein Interacting Protein Info
UniProt ID
GTF2I_HUMAN 
Synonyms BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [52]
Interacting Protein Name Transcriptional repressor p66-alpha (GATAD2A) Interacting Protein Interacting Protein Info
UniProt ID
P66A_HUMAN 
Synonyms p66alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [12]
Interacting Protein Name PHD finger protein 21A (PHF21A) Interacting Protein Interacting Protein Info
UniProt ID
PF21A_HUMAN 
Synonyms BHC80
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Reconstituted Complex [53]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [26]
2 Reconstituted Complex [54]
Interacting Target Name Kruppel like factor 4 (KLF4) Clinical trial Target Interacting Protein Info
UniProt ID
KLF4_HUMAN 
Synonyms Krueppel-like factor 4; Krueppellike factor 4; Gut-enriched krueppel-like factor; Gutenriched krueppellike factor; GKLF; EZF; Epithelial zinc finger protein EZF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Reconstituted Complex [55]
Interacting Protein Name High mobility group protein 20A (HMG20A) Interacting Protein Interacting Protein Info
UniProt ID
HM20A_HUMAN 
Synonyms HMGX1; HMGXB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Methyl-CpG-binding domain protein 2 (MBD2) Interacting Protein Interacting Protein Info
UniProt ID
MBD2_HUMAN 
Synonyms DMTase; NY.CO.41
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Mesoderm induction early response protein 1 (MIER1) Interacting Protein Interacting Protein Info
UniProt ID
MIER1_HUMAN 
Synonyms ER1; MI.ER1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Transcriptional repressor p66-beta (GATAD2B) Interacting Protein Interacting Protein Info
UniProt ID
P66B_HUMAN 
Synonyms MRD18; P66beta; p68
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name REST corepressor 2 (RCOR2) Interacting Protein Interacting Protein Info
UniProt ID
RCOR2_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name REST corepressor 3 (RCOR3) Interacting Protein Interacting Protein Info
UniProt ID
RCOR3_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Ras-responsive element-binding protein 1 (RREB1) Interacting Protein Interacting Protein Info
UniProt ID
RREB1_HUMAN 
Synonyms FINB; HNT; LZ321; RREB.1; Zep.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) Interacting Protein Interacting Protein Info
UniProt ID
TDIF1_HUMAN 
Synonyms C20orf167; Tdif1; dJ447F3.4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Zinc finger protein 217 (ZNF217) Interacting Protein Interacting Protein Info
UniProt ID
ZN217_HUMAN 
Synonyms Zinc finger protein 217; ZABC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [56]
2 Affinity Capture-Western [57]
Other proteins [+] 12 Other proteins +
Interacting Protein Name Paired amphipathic helix protein Sin3a (SIN3A) Interacting Protein Interacting Protein Info
UniProt ID
SIN3A_HUMAN 
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [58]
6 Affinity Capture-Western [59]
7 Affinity Capture-Western [60]
8 Affinity Capture-Western [61]
9 Affinity Capture-Western [62]
10 Affinity Capture-Western [63]
11 Co-fractionation [30]
Interacting Protein Name Metastasis-associated protein MTA2 (MTA2) Interacting Protein Interacting Protein Info
UniProt ID
MTA2_HUMAN 
Synonyms MTA1L1; PID
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [38]
5 Co-fractionation [30]
6 Co-fractionation [12]
Interacting Target Name Chromobox protein homolog 7 (CBX7) Literature-reported Target Interacting Protein Info
UniProt ID
CBX7_HUMAN 
Synonyms Chromobox 7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [64]
2 Affinity Capture-Western [64]
3 Biochemical Activity [64]
4 Co-localization [65]
5 Reconstituted Complex [64]
Interacting Protein Name Genetic suppressor element 1 (GSE1) Interacting Protein Interacting Protein Info
UniProt ID
GSE1_HUMAN 
Synonyms KIAA0182
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Metastasis-associated protein MTA3 (MTA3) Interacting Protein Interacting Protein Info
UniProt ID
MTA3_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [30]
Interacting Protein Name Histone deacetylase complex subunit SAP30 (SAP30) Interacting Protein Interacting Protein Info
UniProt ID
SAP30_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [15]
Interacting Protein Name Zinc finger MYM-type protein 2 (ZMYM2) Interacting Protein Interacting Protein Info
UniProt ID
ZMYM2_HUMAN 
Synonyms FIM; MYM; RAMP; SCLL; ZNF198
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Reconstituted Complex [54]
Interacting Protein Name Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) Interacting Protein Interacting Protein Info
UniProt ID
CDKA1_HUMAN 
Synonyms DOC1; DORC1; ST19; doc.1; p12DOC.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name ELM2 and SANT domain-containing protein 1 (ELMSAN1) Interacting Protein Interacting Protein Info
UniProt ID
EMSA1_HUMAN 
Synonyms C14orf117; C14orf43; LSR68; c14_5541
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [67]
2 Reconstituted Complex [68]
Interacting Protein Name Histone deacetylase complex subunit SAP130 (SAP130) Interacting Protein Interacting Protein Info
UniProt ID
SP130_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [3]
References  Top
REF 1 A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem. 2003 Feb 28;278(9):7234-9.
REF 2 Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65.
REF 3 The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 2013;9:672.
REF 4 NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell. 1998 Dec;2(6):851-61.
REF 5 Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature. 1998 Oct 29;395(6705):917-21.
REF 6 Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry. 1999 Nov 2;38(44):14711-7.
REF 7 A chromatin remodelling complex that loads cohesin onto human chromosomes. Nature. 2002 Aug 29;418(6901):994-8.
REF 8 Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 2010 Jul 16;285(29):21951-60.
REF 9 Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. Biochem J. 2006 Oct 15;399(2):297-304.
REF 10 Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Genes Dev. 2001 Mar 1;15(5):603-18.
REF 11 Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J. 2005 Apr 6;24(7):1406-17.
REF 12 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 13 HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol. 2009 Mar;46(3):292-9.
REF 14 Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol Cell Biol. 2003 May;23(9):3091-102.
REF 15 Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys. 2010 Jun 1;498(1):62-73.
REF 16 Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem. 2007 Nov 9;282(45):33227-36.
REF 17 Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70. J Biol Chem. 2002 Mar 15;277(11):9590-7.
REF 18 Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res. 2004 Aug 1;10(15):5271-81.
REF 19 Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet. 1999 Dec;23(4):474-8.
REF 20 Isolation and characterization of a novel class II histone deacetylase, HDAC10. J Biol Chem. 2002 Feb 22;277(8):6656-66.
REF 21 A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3519-24.
REF 22 A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death. Biochem Biophys Res Commun. 2009 Jan 16;378(3):332-7.
REF 23 Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions. J Biol Chem. 2002 May 31;277(22):19618-26.
REF 24 Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication. J Biol Chem. 2012 May 4;287(19):15622-34.
REF 25 The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. Biochim Biophys Acta. 2007 Oct;1771(10):1271-82.
REF 26 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 27 RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol Cell Biol. 1999 Oct;19(10):6632-41.
REF 28 Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein. Oncogene. 2001 Sep 27;20(43):6152-63.
REF 29 The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. J Biol Chem. 2002 Sep 27;277(39):35783-6.
REF 30 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 31 Cdyl: a new transcriptional co-repressor. EMBO Rep. 2003 Sep;4(9):877-82.
REF 32 The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2613-8.
REF 33 DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet. 2000 Jul;25(3):269-77.
REF 34 The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Oncogene. 2014 Apr 24;33(17):2157-68.
REF 35 LSH cooperates with DNA methyltransferases to repress transcription. Mol Cell Biol. 2008 Jan;28(1):215-26.
REF 36 DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun. 2004 May 28;318(2):544-55.
REF 37 EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. 2012 Feb 2;31(5):583-94.
REF 38 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem. 2001 Mar 2;276(9):6817-24.
REF 39 A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7420-5.
REF 40 The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes. Neoplasia. 2005 Jun;7(6):614-22.
REF 41 Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex. Mol Cell Biol. 2008 Jan;28(1):269-81.
REF 42 Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J. 2004 Mar 10;23(5):1144-54.
REF 43 Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression. Oncogene. 2010 May 27;29(21):3153-62.
REF 44 Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol. 2001 Jan;3(1):30-7.
REF 45 Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem. 2010 Mar 26;285(13):10044-52.
REF 46 Histone deacetylases augment cytokine induction of the iNOS gene. J Am Soc Nephrol. 2002 Aug;13(8):2009-17.
REF 47 Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation. FASEB J. 2010 Jun;24(6):1971-80.
REF 48 N-Myc-interacting protein (NMI) negatively regulates epithelial-mesenchymal transition by inhibiting the acetylation of NF-B/p65. Cancer Lett. 2016 Jun 28;376(1):22-33.
REF 49 CoREST is an integral component of the CoREST- human histone deacetylase complex. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1454-8.
REF 50 BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. Oncogene. 2005 Oct 13;24(45):6753-64.
REF 51 Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. J Biol Chem. 2004 Jan 9;279(2):1562-9.
REF 52 Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. J Biol Chem. 2003 Jan 17;278(3):1841-7.
REF 53 Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Biochem Biophys Res Commun. 2004 Sep 17;322(2):601-8.
REF 54 FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001 Oct 15;15(20):2675-86.
REF 55 All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Biochem Biophys Res Commun. 2009 Sep 11;387(1):13-8.
REF 56 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 57 Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. Mol Cell Biol. 2008 Oct;28(19):6066-77.
REF 58 Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell. 1997 May 2;89(3):349-56.
REF 59 Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem. 2002 Aug 30;277(35):31826-33.
REF 60 Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):401-14.
REF 61 Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. J Biol Chem. 2002 Sep 6;277(36):33431-8.
REF 62 Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A. J Biol Chem. 2004 Apr 9;279(15):14922-8.
REF 63 Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress. J Mol Cell Biol. 2012 Oct;4(5):284-93.
REF 64 Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res. 2009 Sep 1;69(17):7079-87.
REF 65 CBX7 is a tumor suppressor in mice and humans. J Clin Invest. 2012 Feb;122(2):612-23.
REF 66 pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases. Mol Cells. 2012 Feb;33(2):195-201.
REF 67 MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks. Mol Cell Biol. 2008 Oct;28(19):5912-23.
REF 68 The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol. 2001 Apr;21(7):2259-68.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.