Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T20761 Target Info
Target Name Vascular endothelial growth factor A (VEGFA)
Synonyms Vascular permeability factor; VPF; VEGF-A; VEGF
Target Type Successful Target
Gene Name VEGFA
Biochemical Class Growth factor
UniProt ID
P15692
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-126-3p miRNA Info
miRNA Mature AC
MIMAT0000445
Sequence ucguaccgugaguaauaaugcg
miRNA Species Homo sapiens
Evidence Score (E-score) 7 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay [2]
3 Luciferase Reporter Assay [3]
4 Luciferase Reporter Assay; qRT-PCR; Western Blot [4]
5 Luciferase Reporter Assay; qRT-PCR; Western Blot [5]
6 Luciferase Reporter Assay; qRT-PCR; Western Blot [6]
7 Luciferase Reporter Assay; Western Blot [7]
Representative Target(s) Regulated by This miRNA Adrenomedullin (ADM) Target Info
ADML_HUMAN
Angiopoietin 1 receptor (TEK) Target Info
TIE2_HUMAN
miRNA Mature ID hsa-miR-15a-5p miRNA Info
miRNA Mature AC
MIMAT0000068
Sequence uagcagcacauaaugguuugug
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-15a-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 5 +
1 ELISA; Immunohistochemistry; Luciferase Reporter Assay; qRT-PCR; Western Blot [8]
2 Immunoblot; Luciferase Reporter Assay; qRT-PCR [9]
3 Immunoblot; Luciferase Reporter Assay; qRT-PCR [3]
4 Luciferase Reporter Assay [10]
5 Luciferase Reporter Assay; qRT-PCR; Western Blot [11]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-205-5p miRNA Info
miRNA Mature AC
MIMAT0000266
Sequence uccuucauuccaccggagucug
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-205-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 5 +
1 Luciferase Reporter Assay [12]
2 Luciferase Reporter Assay [13]
3 Luciferase Reporter Assay [3]
4 Luciferase Reporter Assay; qRT-PCR; Western Blot [14]
5 Luciferase Reporter Assay; qRT-PCR; Western Blot [15]
Representative Target(s) Regulated by This miRNA Androgen receptor (AR) Target Info
ANDR_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-361-5p miRNA Info
miRNA Mature AC
MIMAT0000703
Sequence uuaucagaaucuccagggguac
miRNA Species Homo sapiens
Regulation Mechanism SRIF limits VEGF release through its interaction with miR-361 indicates that miR-361 participates in the adaptive response of HUVEC to hypoxia. [18]
Evidence Score (E-score) 4 +
1 ELISA; Luciferase Reporter Assay [3]
2 ELISA; Luciferase Reporter Assay; qRT-PCR [16]
3 Luciferase Reporter Assay; Western Blot [17]
4 qRT-PCR; Western Blot [18]
Representative Target(s) Regulated by This miRNA C-X-C chemokine receptor type 6 (CXCR6) Target Info
CXCR6_HUMAN
Signal transducer and activator of transcription 6 (STAT6) Target Info
STAT6_HUMAN
miRNA Mature ID hsa-miR-140-5p miRNA Info
miRNA Mature AC
MIMAT0000431
Sequence cagugguuuuacccuaugguag
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-140-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 3 +
1 ELISA; Luciferase Reporter Assay [3]
2 Luciferase Reporter Assay; qRT-PCR; Western Blot [19]
3 Luciferase Reporter Assay; Western Blot [20]
Representative Target(s) Regulated by This miRNA Adenosine deaminase (ADA) Target Info
ADA_HUMAN
Aspartyl aminopeptidase (DNPEP) Target Info
DNPEP_HUMAN
miRNA Mature ID hsa-miR-200b-3p miRNA Info
miRNA Mature AC
MIMAT0000318
Sequence uaauacugccugguaaugauga
miRNA Species Homo sapiens
Regulation Mechanism Direct targets of miR-200b are VEGF and its receptors, Flt1 and KDR, which play a pivotal role in VEGF signaling. [22]
Evidence Score (E-score) 3 +
1 Luciferase Reporter Assay [21]
2 Luciferase Reporter Assay; Western Blot [22]
3 qRT-PCR; Western Blot [23]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
CDK inhibitor 1B p27Kip1 (CDKN1B) Target Info
CDN1B_HUMAN
miRNA Mature ID hsa-miR-145-5p miRNA Info
miRNA Mature AC
MIMAT0000437
Sequence guccaguuuucccaggaaucccu
miRNA Species Homo sapiens
Regulation Mechanism miR-145 plays important inhibitory role in breast cancer malignancy by targeting VeGF-A, which may be potential therapeutic and diagnostic target. [24]
Evidence Score (E-score) 3 +
1 Immunoblot; Immunohistochemistry; Luciferase Reporter Assay; Northern Blot [24]
2 Luciferase Reporter Assay; qRT-PCR; Western Blot [25]
3 Luciferase Reporter Assay; qRT-PCR; Western Blot [26]
Representative Target(s) Regulated by This miRNA A proliferation-inducing ligand (APRIL) Target Info
TNF13_HUMAN
Alkaline phosphatase (ALPPL2) Target Info
PPBN_HUMAN
miRNA Mature ID hsa-miR-195-5p miRNA Info
miRNA Mature AC
MIMAT0000461
Sequence uagcagcacagaaauauuggc
miRNA Species Homo sapiens
Evidence Score (E-score) 3 +
1 ELISA; Luciferase Reporter Assay [27]
2 ELISA; Luciferase Reporter Assay [3]
3 Luciferase Reporter Assay [28]
Representative Target(s) Regulated by This miRNA ADP-ribosylation factor-like protein 2 (ARL2) Target Info
ARL2_HUMAN
Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
miRNA Mature ID hsa-miR-29a-3p miRNA Info
miRNA Mature AC
MIMAT0000086
Sequence uagcaccaucugaaaucgguua
miRNA Species Homo sapiens
Evidence Score (E-score) 3 +
1 Immunohistochemistry; Luciferase Reporter Assay; qRT-PCR; Western Blot [29]
2 Luciferase Reporter Assay; qRT-PCR; Western Blot [30]
3 PAR-CLIP [31]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Aryl hydrocarbon receptor (AHR) Target Info
AHR_HUMAN
miRNA Mature ID hsa-miR-106b-5p miRNA Info
miRNA Mature AC
MIMAT0000680
Sequence uaaagugcugacagugcagau
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay [3]
2 Microarray [32]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-125a-5p miRNA Info
miRNA Mature AC
MIMAT0000443
Sequence ucccugagacccuuuaaccuguga
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay [3]
2 ELISA; Luciferase Reporter Assay; qRT-PCR; Western Blot [33]
Representative Target(s) Regulated by This miRNA Apoptosis regulator BAK (BAK) Target Info
BAK_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-200c-3p miRNA Info
miRNA Mature AC
MIMAT0000617
Sequence uaauacugccggguaaugaugga
miRNA Species Homo sapiens
Regulation Mechanism miR-200c Targets the Expression of VEGFA and Alters Cellular Proliferation. [35]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [34]
2 Luciferase Reporter Assay; Western Blot [35]
Representative Target(s) Regulated by This miRNA Activin receptor type IIB (ACVR2B) Target Info
AVR2B_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-206 miRNA Info
miRNA Mature AC
MIMAT0000462
Sequence uggaauguaaggaagugugugg
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay; qRT-PCR; Western Blot [36]
2 PAR-CLIP [37]
Representative Target(s) Regulated by This miRNA Annexin A2 (ANXA2) Target Info
ANXA2_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-20a-5p miRNA Info
miRNA Mature AC
MIMAT0000075
Sequence uaaagugcuuauagugcagguag
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay [3]
2 Luciferase Reporter Assay [38]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-20b-5p miRNA Info
miRNA Mature AC
MIMAT0001413
Sequence caaagugcucauagugcagguag
miRNA Species Homo sapiens
Regulation Mechanism VEGFa is the direct targets of miR-20b. [39]
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay [3]
2 Luciferase Reporter Assay; Western Blot [39]
Representative Target(s) Regulated by This miRNA Cyclin-dependent kinase 2 (CDK2) Target Info
CDK2_HUMAN
Cyclin-dependent kinase 6 (CDK6) Target Info
CDK6_HUMAN
miRNA Mature ID hsa-miR-21-5p miRNA Info
miRNA Mature AC
MIMAT0000076
Sequence uagcuuaucagacugauguuga
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 qRT-PCR [40]
2 Western Blot; qRT-PCR [41]
Representative Target(s) Regulated by This miRNA Apoptosis antigen ligand (CD178) Target Info
TNFL6_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-29c-3p miRNA Info
miRNA Mature AC
MIMAT0000681
Sequence uagcaccauuugaaaucgguua
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Immunohistochemistry; Luciferase Reporter Assay; qRT-PCR; Western Blot [29]
2 Sequencing; PAR-CLIP [31]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
B7 homolog 3 (CD276) Target Info
CD276_HUMAN
miRNA Mature ID hsa-miR-378a-3p miRNA Info
miRNA Mature AC
MIMAT0000732
Sequence acuggacuuggagucagaaggc
miRNA Species Homo sapiens
Regulation Mechanism miR-378 is abnormally expressed and epigenetically regulated in gastric cancer cell lines and tissues via the suppression of VEGFA , suggesting that miR-378 has tumor suppressor properties in gastric cancer. [42]
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay [3]
2 Luciferase Reporter Assay; Western Blot [42]
Representative Target(s) Regulated by This miRNA Aromatase (CYP19A1) Target Info
CP19A_HUMAN
Cyclin-dependent kinase 6 (CDK6) Target Info
CDK6_HUMAN
miRNA Mature ID hsa-miR-503-5p miRNA Info
miRNA Mature AC
MIMAT0002874
Sequence uagcagcgggaacaguucugcag
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [43]
2 PAR-CLIP [31]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
CD40L receptor (CD40) Target Info
TNR5_HUMAN
miRNA Mature ID hsa-miR-93-5p miRNA Info
miRNA Mature AC
MIMAT0000093
Sequence caaagugcuguucgugcagguag
miRNA Species Homo sapiens
Regulation Mechanism miR-93 represses VEGFA expression by targeting 3'UTR directly. [44]
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay [3]
2 Luciferase Reporter Assay; Western Blot [44]
Representative Target(s) Regulated by This miRNA Angiogenin (ANG) Target Info
ANGI_HUMAN
ATP-binding cassette transporter A1 (ABCA1) Target Info
ABCA1_HUMAN
miRNA Mature ID hsa-miR-106a-5p miRNA Info
miRNA Mature AC
MIMAT0000103
Sequence aaaagugcuuacagugcagguag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-107 miRNA Info
miRNA Mature AC
MIMAT0000104
Sequence agcagcauuguacagggcuauca
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Beta-secretase 1 (BACE1) Target Info
BACE1_HUMAN
Caveolin 1 (CAV1) Target Info
CAV1_HUMAN
miRNA Mature ID hsa-miR-125a-3p miRNA Info
miRNA Mature AC
MIMAT0004602
Sequence acaggugagguucuugggagcc
miRNA Species Homo sapiens
Regulation Mechanism VEGFA is a target gene of miR125a and miR125a had binding sites in the 3'UTR region of VEGF-A mRNA. [33]
Evidence Score (E-score) 1 +
1 Immunohistochemistry; Luciferase Reporter Assay; Western Blot [33]
Representative Target(s) Regulated by This miRNA Enhancer of zeste homolog 2 (EZH2) Target Info
EZH2_HUMAN
Fyn tyrosine protein kinase (FYN) Target Info
FYN_HUMAN
miRNA Mature ID hsa-miR-126-5p miRNA Info
miRNA Mature AC
MIMAT0000444
Sequence cauuauuacuuuugguacgcg
miRNA Species Homo sapiens
Regulation Mechanism miR-126-5p down-regulated VEGFA expression by binding to its 3'UTR. [45]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [45]
Representative Target(s) Regulated by This miRNA Matrix metalloproteinase-7 (MMP-7) Target Info
MMP7_HUMAN
Proto-oncogene c-Crk (c-Crk) Target Info
CRK_HUMAN
miRNA Mature ID hsa-miR-134-5p miRNA Info
miRNA Mature AC
MIMAT0000447
Sequence ugugacugguugaccagagggg
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Angiopoietin-related protein 4 (ANGPTL4) Target Info
ANGL4_HUMAN
Erbb2 tyrosine kinase receptor (HER2) Target Info
ERBB2_HUMAN
miRNA Mature ID hsa-miR-150-5p miRNA Info
miRNA Mature AC
MIMAT0000451
Sequence ucucccaacccuuguaccagug
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
Beta-arrestin-2 (ARRB2) Target Info
ARRB2_HUMAN
miRNA Mature ID hsa-miR-15b-5p miRNA Info
miRNA Mature AC
MIMAT0000417
Sequence uagcagcacaucaugguuuaca
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Checkpoint kinase-1 (CHK1) Target Info
CHK1_HUMAN
miRNA Mature ID hsa-miR-16-1-3p miRNA Info
miRNA Mature AC
MIMAT0004489
Sequence ccaguauuaacugugcugcuga
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [46]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
G1/S-specific cyclin-D1 (CCND1) Target Info
CCND1_HUMAN
miRNA Mature ID hsa-miR-16-5p miRNA Info
miRNA Mature AC
MIMAT0000069
Sequence uagcagcacguaaauauuggcg
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-16-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Corticotropin-releasing factor binding protein (CRHBP) Target Info
CRHBP_HUMAN
miRNA Mature ID hsa-miR-17-5p miRNA Info
miRNA Mature AC
MIMAT0000070
Sequence caaagugcuuacagugcagguag
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-17-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-185-5p miRNA Info
miRNA Mature AC
MIMAT0000455
Sequence uggagagaaaggcaguuccuga
miRNA Species Homo sapiens
Regulation Mechanism Vegfa is a direct target gene of miR-185 that inhibits Vegfa expression through binding to seed sequence in Vegfa 3'UTR. [47]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [47]
Representative Target(s) Regulated by This miRNA Androgen receptor (AR) Target Info
ANDR_HUMAN
Arachidonate 12-lipoxygenase (12-LOX) Target Info
LOX12_HUMAN
miRNA Mature ID hsa-miR-186-5p miRNA Info
miRNA Mature AC
MIMAT0000456
Sequence caaagaauucuccuuuugggcu
miRNA Species Homo sapiens
Regulation Mechanism miR-186 dramatically decreased the luciferase activity of reporter plasmid with the VEGF 3'UTR. [9]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [9]
Representative Target(s) Regulated by This miRNA Casein kinase II alpha (CSNK2A1) Target Info
CSK21_HUMAN
Fibroblast growth factor-2 (FGF2) Target Info
FGF2_HUMAN
miRNA Mature ID hsa-miR-203a-3p miRNA Info
miRNA Mature AC
MIMAT0000264
Sequence gugaaauguuuaggaccacuag
miRNA Species Homo sapiens
Regulation Mechanism miR-203 suppressed cervical cancer cell proliferation and angiogenesis by targeting VEGFA. [48]
Evidence Score (E-score) 1 +
1 Immunohistochemistry; Luciferase Reporter Assay; Western Blot [48]
Representative Target(s) Regulated by This miRNA Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
Apoptosis regulator Bcl-W (BCL-W) Target Info
B2CL2_HUMAN
miRNA Mature ID hsa-miR-296-5p miRNA Info
miRNA Mature AC
MIMAT0000690
Sequence agggcccccccucaauccugu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [49]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Bcl-2-binding component 3 (BBC3) Target Info
BBC3_HUMAN
miRNA Mature ID hsa-miR-302d-3p miRNA Info
miRNA Mature AC
MIMAT0000718
Sequence uaagugcuuccauguuugagugu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Cyclin-dependent kinase 2 (CDK2) Target Info
CDK2_HUMAN
Erbb4 tyrosine kinase receptor (Erbb-4) Target Info
ERBB4_HUMAN
miRNA Mature ID hsa-miR-330-3p miRNA Info
miRNA Mature AC
MIMAT0000751
Sequence gcaaagcacacggccugcagaga
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA E2F transcription factor 1 (E2F1) Target Info
E2F1_HUMAN
Extracellular matrix receptor III (CD44) Target Info
CD44_HUMAN
miRNA Mature ID hsa-miR-34a-5p miRNA Info
miRNA Mature AC
MIMAT0000255
Sequence uggcagugucuuagcugguugu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-34a-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Amphiregulin (AREG) Target Info
AREG_HUMAN
Androgen receptor (AR) Target Info
ANDR_HUMAN
miRNA Mature ID hsa-miR-34b-3p miRNA Info
miRNA Mature AC
MIMAT0004676
Sequence caaucacuaacuccacugccau
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Cyclic AMP-responsive element-binding protein (CREB1) Target Info
CREB1_HUMAN
miRNA Mature ID hsa-miR-34b-5p miRNA Info
miRNA Mature AC
MIMAT0000685
Sequence uaggcagugucauuagcugauug
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-34b-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Beta-catenin (CTNNB1) Target Info
CTNB1_HUMAN
miRNA Mature ID hsa-miR-372-3p miRNA Info
miRNA Mature AC
MIMAT0000724
Sequence aaagugcugcgacauuugagcgu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-372-3p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA ATPase family AAA domain containing 2 (ATAD2) Target Info
ATAD2_HUMAN
B-cell translocation gene 1 protein (BTG1) Target Info
BTG1_HUMAN
miRNA Mature ID hsa-miR-373-3p miRNA Info
miRNA Mature AC
MIMAT0000726
Sequence gaagugcuucgauuuuggggugu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA B-cell translocation gene 1 protein (BTG1) Target Info
BTG1_HUMAN
Cell surface protein HB15 (CD83) Target Info
CD83_HUMAN
miRNA Mature ID hsa-miR-383-5p miRNA Info
miRNA Mature AC
MIMAT0000738
Sequence agaucagaaggugauuguggcu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA A proliferation-inducing ligand (APRIL) Target Info
TNF13_HUMAN
G1/S-specific cyclin-D1 (CCND1) Target Info
CCND1_HUMAN
miRNA Mature ID hsa-miR-429 miRNA Info
miRNA Mature AC
MIMAT0001536
Sequence uaauacugucugguaaaaccgu
miRNA Species Homo sapiens
Regulation Mechanism miR429 decreased the 3'UTR luciferase activity of vascular endothelial growth factor (VEGF). [50]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [50]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
DNA [cytosine-5]-methyltransferase 1 (DNMT1) Target Info
DNMT1_HUMAN
miRNA Mature ID hsa-miR-504-5p miRNA Info
miRNA Mature AC
MIMAT0002875
Sequence agacccuggucugcacucuauc
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-504-5p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
Bcl-2-binding component 3 (BBC3) Target Info
BBC3_HUMAN
miRNA Mature ID hsa-miR-205-3p miRNA Info
miRNA Mature AC
MIMAT0009197
Sequence gauuucaguggagugaaguuc
miRNA Species Homo sapiens
Regulation Mechanism miR-205 directly binds VEGFA mRNA 3'UTR and miR-205 levels are negatively correlated with VEGFA mRNA expression in breast cancer patients. [51]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay; Western Blot [51]
Representative Target(s) Regulated by This miRNA Fibroblast growth factor-2 (FGF2) Target Info
FGF2_HUMAN
Vascular endothelial growth factor A (VEGFA) Target Info
VEGFA_HUMAN
miRNA Mature ID hsa-miR-374b-5p miRNA Info
miRNA Mature AC
MIMAT0004955
Sequence auauaauacaaccugcuaagug
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 PAR-CLIP [52]
Representative Target(s) Regulated by This miRNA RAC-alpha serine/threonine-protein kinase (AKT1) Target Info
AKT1_HUMAN
Suppressor of tumorigenicity 15 protein (ST15) Target Info
RECK_HUMAN
miRNA Mature ID hsa-miR-520g-3p miRNA Info
miRNA Mature AC
MIMAT0002858
Sequence acaaagugcuucccuuuagagugu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-520g-3p by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Matrix metalloproteinase-2 (MMP-2) Target Info
MMP2_HUMAN
Vascular endothelial growth factor A (VEGFA) Target Info
VEGFA_HUMAN
miRNA Mature ID hsa-miR-520h miRNA Info
miRNA Mature AC
MIMAT0002867
Sequence acaaagugcuucccuuuagagu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-520h by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter G2 (ABCG2) Target Info
ABCG2_HUMAN
Histone deacetylase 1 (HDAC1) Target Info
HDAC1_HUMAN
miRNA Mature ID hsa-miR-718 miRNA Info
miRNA Mature AC
MIMAT0012735
Sequence cuuccgccccgccgggcgucg
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [53]
Representative Target(s) Regulated by This miRNA Phosphatase and tensin homolog (PTEN) Target Info
PTEN_HUMAN
Vascular endothelial growth factor A (VEGFA) Target Info
VEGFA_HUMAN
miRNA Mature ID hsa-miR-942-3p miRNA Info
miRNA Mature AC
MIMAT0026734
Sequence cacauggccgaaacagagaagu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [54]
Representative Target(s) Regulated by This miRNA Matrix metalloproteinase-9 (MMP-9) Target Info
MMP9_HUMAN
Vascular endothelial growth factor A (VEGFA) Target Info
VEGFA_HUMAN
miRNA Mature ID hsa-miR-147a miRNA Info
miRNA Mature AC
MIMAT0000251
Sequence guguguggaaaugcuucugc
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-147a by siRNA transfection resulted in the decreased protein level of target VEGFA. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Vascular endothelial growth factor A (VEGFA) Target Info
VEGFA_HUMAN
References  Top
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REF 2 MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer. 2009 Nov;66(2):169-75.
REF 3 The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719.
REF 4 Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A. Oncotarget. 2014 Dec 15;5(23):11873-85.
REF 5 Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer. Oncol Rep. 2013 Oct;30(4):1976-84.
REF 6 miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A. Acta Biochim Biophys Sin (Shanghai). 2012 Jun;44(6):519-26.
REF 7 Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem. 2011 May;351(1-2):157-64.
REF 8 MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Biosci Trends. 2017 Jan 16;10(6):482-488.
REF 9 Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer. Oncotarget. 2016 Jul 12;7(28):44350-44364.
REF 10 MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia. Circ Res. 2013 Jan 18;112(2):335-46.
REF 11 miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF. Carcinogenesis. 2013 Feb;34(2):426-35.
REF 12 miRNA-dependent cross-talk between VEGF and Ang-2 in hypoxia-induced microvascular dysfunction. Biochem Biophys Res Commun. 2014 Sep 26;452(3):428-35.
REF 13 Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res. 2009 Apr;19(4):439-48.
REF 14 miR-205 suppresses the proliferative and migratory capacity of human osteosarcoma Mg-63 cells by targeting VEGFA. Onco Targets Ther. 2015 Sep 16;8:2635-42.
REF 15 MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A. Oncol Rep. 2012 Apr;27(4):1200-6.
REF 16 The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma. PLoS One. 2012;7(11):e49568.
REF 17 miR-361-5p inhibits hepatocellular carcinoma cell proliferation and invasion by targeting VEGFA. Biochem Biophys Res Commun. 2016 Oct 28;479(4):901-906.
REF 18 Antiangiogenic role of miR-361 in human umbilical vein endothelial cells: functional interaction with the peptide somatostatin. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):15-27.
REF 19 MicroRNA-140-5p inhibits the progression of colorectal cancer by targeting VEGFA. Cell Physiol Biochem. 2015;37(3):1123-33.
REF 20 miR 40 p regulates angiogenesis following ischemic stroke by targeting VEGFA. Mol Med Rep. 2016 May;13(5):4499-505.
REF 21 Effects of miRNA-200b on the development of diabetic retinopathy by targeting VEGFA gene. Biosci Rep. 2017 Mar 15;37(2). pii: BSR20160572.
REF 22 Regulation of vascular endothelial growth factor signaling by miR-200b. Mol Cells. 2011 Jul;32(1):77-82.
REF 23 Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy. PLoS One. 2015 Apr 17;10(4):e0123987.
REF 24 MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF. Cell Cycle. 2012 Jun 1;11(11):2137-45.
REF 25 Argonaute 2 promotes myeloma angiogenesis via microRNA dysregulation. J Hematol Oncol. 2014 May 7;7:40.
REF 26 MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. Acta Biochim Biophys Sin (Shanghai). 2012 May;44(5):407-14.
REF 27 MiR-195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14110-20.
REF 28 MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42. Hepatology. 2013 Aug;58(2):642-53.
REF 29 Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma. Cancer Lett. 2016 Jun 1;375(2):331-339.
REF 30 miR-29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF-A. BMB Rep. 2014 Jan;47(1):39-44.
REF 31 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41.
REF 32 Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol Cell Biol. 2007 Mar;27(6):2240-52.
REF 33 miR-125a regulates angiogenesis of gastric cancer by targeting vascular endothelial growth factor A. Int J Oncol. 2015 Nov;47(5):1801-10.
REF 34 miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5. Endocr Relat Cancer. 2012 Jul 22;19(4):541-56.
REF 35 Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLT1, IKK, KLF9, and FBLN5. Reprod Sci. 2012 Aug;19(8):786-96.
REF 36 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. PLoS Genet. 2016 Aug 19;12(8):e1006244.
REF 37 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 38 MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis. Cancer Lett. 2016 Jul 1;376(2):293-302.
REF 39 Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1 and VEGF Effect on Cell Biological Behaviour. Dis Markers. 2015;2015:325176.
REF 40 MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther. 2009 May;8(5):1067-74.
REF 41 MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1 expression. PLoS One. 2011 Apr 22;6(4):e19139.
REF 42 MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer. Gene. 2013 Apr 15;518(2):351-9.
REF 43 MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer Lett. 2013 Jun 10;333(2):159-69.
REF 44 Down regulation of MiR-93 contributes to endometriosis through targeting MMP3 and VEGFA. Am J Cancer Res. 2015 Apr 15;5(5):1706-17.
REF 45 Down-regulation of microRNA-126-5p contributes to overexpression of VEGFA in lipopolysaccharide-induced acute lung injury. Biotechnol Lett. 2016 Aug;38(8):1277-84.
REF 46 MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma. Leuk Res. 2016 Oct;49:73-9.
REF 47 MiR-185 is involved in human breast carcinogenesis by targeting Vegfa. FEBS Lett. 2014 Nov 28;588(23):4438-47.
REF 48 miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem. 2013;32(1):64-73.
REF 49 Prongiogenic microRNA 96 upregulatesvascular endothelial growth factor and downregulates Notch1 following cerebral ischemic injury. Mol Med Rep. 2015 Dec;12(6):8141-7.
REF 50 Tumor suppressive microRNA 29 regulates cellular function by targeting VEGF in clear cell renal cell carcinoma. Mol Med Rep. 2016 Feb;13(2):1361-6.
REF 51 miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer. Cell Death Dis. 2016 Jun 30;7(6):e2291.
REF 52 Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013 Mar 21;495(7441):333-8.
REF 53 MiR-718 represses VEGF and inhibits ovarian cancer cell progression. FEBS Lett. 2014 Jun 5;588(12):2078-86.
REF 54 Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS One. 2014 Jan 24;9(1):e86263.

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