Target Information
Target General Infomation | |||||
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Target ID |
T32060
|
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Former ID |
TTDS00103
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Target Name |
5-hydroxytryptamine 2A receptor
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Gene Name |
HTR2A
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Synonyms |
5-HT-2; 5-HT-2A; 5-HT2A receptor; 5-hydroxytryptamine receptor 2A; Serotonin receptor; Serotonin receptor 2A; HTR2A
|
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Target Type |
Successful
|
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Disease | Addiction [ICD code not available] | ||||
Alcohol use disorders [ICD9: 303; ICD10: F10.2] | |||||
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | |||||
Cardiovascular disorder [ICD10: I00-I99] | |||||
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63] | |||||
Central nervous system disease [ICD10: G00-G99] | |||||
Depression [ICD9: 311; ICD10: F30-F39] | |||||
Diabetes [ICD9: 253.5, 588.1; ICD10: E23.2, N25.1] | |||||
Erythropoietic porphyria [ICD10: E80.0] | |||||
Female sexual dysfunction [ICD9: 302.7; ICD10: F52] | |||||
Fibromyalgia [ICD9: 729.1; ICD10: M79.7] | |||||
Glaucoma [ICD9: 365; ICD10: H40-H42] | |||||
Hypertension [ICD9: 401; ICD10: I10-I16] | |||||
Hemorrhoids [ICD10: I84] | |||||
Migraine [ICD9: 346; ICD10: G43] | |||||
Mood disorder [ICD10: F30-F39] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Psychiatric disorder [ICD9: 290-319; ICD10: F01-F99] | |||||
Pancreatitis [ICD9: 577.0-577.1; ICD10: K85, K86.0K86.1] | |||||
Parkinson's disease; Psychosis; Schizophrenia [ICD9:290-299, 332, 295; ICD10: F02.3, F20-F29, G20, F20] | |||||
Parkinson disease psychosis [ICD10: G00-G99] | |||||
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29] | |||||
Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10: F51, G47] | |||||
Schizophrenia; Sleep maintenance insomnia [ICD9:295, 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F20, F51.0, G47.0] | |||||
Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10: F20, F25] | |||||
Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia [ICD9: 295, 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F20, F51.0, G47.0] | |||||
Severe mood disorders [ICD9: 296; ICD10: F30-F39] | |||||
Schizophrenia [ICD9: 295; ICD10: F20] | |||||
Unspecified [ICD code not available] | |||||
Function |
G-protein coupled receptor for5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
|
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BioChemical Class |
GPCR rhodopsin
|
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Target Validation |
T32060
|
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UniProt ID | |||||
Sequence |
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV |
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Drugs and Mode of Action | |||||
Drug(s) | Abilify Maintena | Drug Info | Approved | Erythropoietic porphyria | [551871] |
Aniracetam | Drug Info | Approved | Cerebrovascular ischaemia | [467478], [526084] | |
Flibanserin | Drug Info | Approved | Mood disorder | [532651], [542987] | |
Iloperidone | Drug Info | Approved | Schizophrenia | [530677], [543255] | |
Lurasidone hydrochloride | Drug Info | Approved | Schizophrenia | [530859], [531351], [542486], [551871] | |
Pimavanserin | Drug Info | Approved | Parkinson disease psychosis | [889440] | |
Sarpogrelate | Drug Info | Approved | Diabetes | [535855], [539330] | |
ZOTEPINE | Drug Info | Approved | Anxiety disorder | [538628], [551871] | |
Blonanserin | Drug Info | Phase 3 | Schizophrenia | [536463], [542649] | |
Flibanserin | Drug Info | Phase 3 | Female sexual dysfunction | [536493], [542987] | |
ITI-007 | Drug Info | Phase 3 | Schizophrenia; Sleep maintenance insomnia | [525226], [549912] | |
Low dose ITI-007 | Drug Info | Phase 3 | Schizophrenia | [548546] | |
M100907 | Drug Info | Phase 3 | Sleep disorders | [522054] | |
Pimavanserin | Drug Info | Phase 3 | Parkinson's disease; Psychosis; Schizophrenia | [543125], [547301] | |
SR46349B | Drug Info | Phase 3 | Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia | [536463] | |
TNX-102 | Drug Info | Phase 3 | Fibromyalgia | [547624] | |
TRYPTAMINE | Drug Info | Phase 3 | Discovery agent | [521730], [538764] | |
VOLINANSERIN | Drug Info | Phase 3 | Discovery agent | [522480], [539159] | |
Zicronapine | Drug Info | Phase 3 | Schizophrenia | [523357] | |
BVT.28949 | Drug Info | Phase 2 | Glaucoma | [548204] | |
Ocaperidone | Drug Info | Phase 2 | Schizophrenia; Schizoaffective disorders | [467839], [526792], [536463] | |
PRUVANSERIN | Drug Info | Phase 2 | Sleep disorders | [521764] | |
1192U90 | Drug Info | Phase 1 | Psychotic disorders | [534252] | |
Abaperidone | Drug Info | Phase 1 | Schizophrenia | [551815] | |
MIN-101 | Drug Info | Phase 1 | Schizophrenia | [524902] | |
SKL-10406 | Drug Info | Phase 1 | Major depressive disorder | [549136] | |
Temanogrel | Drug Info | Phase 1 | Cardiovascular disorder | [524599] | |
YKP-1358 | Drug Info | Phase 1 | Schizophrenia; Schizoaffective disorders | [536463] | |
Org-23366 | Drug Info | Preclinical | Schizophrenia | [536463] | |
LYSERGIC ACID DIETHYLAMIDE | Drug Info | Withdrawn from market | Addiction | [526769], [539053] | |
Deramciclane | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [540889], [544913] | |
Iferanserin-Ventrus | Drug Info | Discontinued in Phase 3 | Hemorrhoids | [547235] | |
MDL-11939 | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [539169], [544618] | |
Ritanserin | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [543335], [544590] | |
TIOSPIRONE | Drug Info | Discontinued in Phase 3 | Discovery agent | [538617], [544679] | |
Adatanserin | Drug Info | Discontinued in Phase 2 | Severe mood disorders | [536580] | |
AMESERGIDE | Drug Info | Discontinued in Phase 2 | Mood disorder | [539285], [544787] | |
ATI-9242 | Drug Info | Discontinued in Phase 2 | Schizophrenia | [548733] | |
FCE-22716 | Drug Info | Discontinued in Phase 2 | Hypertension | [533340] | |
MAZAPERTINE | Drug Info | Discontinued in Phase 2 | Discovery agent | [545274] | |
NELOTANSERIN | Drug Info | Discontinued in Phase 2 | Sleep disorders | [548083] | |
SERAZAPINE HYDROCHLORIDE | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [544867] | |
SERGOLEXOLE MALEATE | Drug Info | Discontinued in Phase 2 | Migraine | [544716] | |
SL65.0472 | Drug Info | Discontinued in Phase 2 | Cardiovascular disorder | [547242] | |
YM-992 | Drug Info | Discontinued in Phase 2 | Depression | [546447] | |
AM-831 | Drug Info | Discontinued in Phase 1 | Schizophrenia | [547459] | |
DUP-734 | Drug Info | Discontinued in Phase 1 | Psychotic disorders | [544981] | |
1192U90 | Drug Info | Terminated | Schizophrenia | [536463] | |
A-80426 | Drug Info | Terminated | Discovery agent | [546043] | |
AMPEROZIDE | Drug Info | Terminated | Alcohol use disorders | [544701] | |
DV-7028 | Drug Info | Terminated | Cardiovascular disorder | [545055] | |
Fananserin | Drug Info | Terminated | Schizophrenia | [536463], [540837] | |
GMC-283 | Drug Info | Terminated | Schizophrenia | [536463] | |
ICI-169369 | Drug Info | Terminated | Anxiety disorder | [539780], [544709] | |
LY53857 | Drug Info | Terminated | Discovery agent | [539138], [544876] | |
MDL-28161 | Drug Info | Terminated | Discovery agent | [544961] | |
R-102444 | Drug Info | Terminated | Pancreatitis | [547365] | |
Ro-60-0175 | Drug Info | Terminated | Discovery agent | [539026], [546467] | |
RP-68303 | Drug Info | Terminated | Discovery agent | [545423] | |
ZD-3638 | Drug Info | Terminated | Schizophrenia | [536463] | |
Agonist | (+)-LSD | Drug Info | [527178] | ||
3,4-Methylenedioxymethamphetamine | Drug Info | [551382] | |||
5-CT | Drug Info | [527178] | |||
Abilify Maintena | Drug Info | [526792], [527134] | |||
ACP-106 | Drug Info | [526792] | |||
AL-37350A | Drug Info | [526713] | |||
alpha-methyl-5-HT | Drug Info | [525890] | |||
AM-831 | Drug Info | [550322] | |||
BRL-15572 | Drug Info | [534475] | |||
BW723C86 | Drug Info | [527178] | |||
DV-7028 | Drug Info | [537955], [538116], [538117] | |||
LP-12 | Drug Info | [528956] | |||
LP-44 | Drug Info | [528956] | |||
m-chlorophenylpiperazine | Drug Info | [534830] | |||
MMDA | Drug Info | [551393] | |||
N-1-isopropyl-5-MeOT | Drug Info | [533905] | |||
N-1-isopropyltryptamine | Drug Info | [533905] | |||
Org 12962 | Drug Info | [527178] | |||
SB 216641 | Drug Info | [534475] | |||
Temanogrel | Drug Info | [526792], [550267] | |||
TFMPP | Drug Info | [527178] | |||
[125I]DOI | Drug Info | [525927] | |||
Inhibitor | (+/-)-nantenine | Drug Info | [530558] | ||
(1-Phenethyl-piperidin-4-yl)-phenyl-methanone | Drug Info | [525963] | |||
(2-Indol-1-yl-ethyl)-dimethyl-amine | Drug Info | [526235] | |||
(2S)-1-(1H-furo[2,3-g]indazol-1-yl)propan-2-amine | Drug Info | [529168] | |||
(2S)-1-(5-fluoro-1H-indazol-1-yl)propan-2-amine | Drug Info | [529168] | |||
(2S)-1-(6-fluoro-1H-indazol-1-yl)propan-2-amine | Drug Info | [529168] | |||
(2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine | Drug Info | [527952] | |||
(E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine | Drug Info | [528690] | |||
(E)-2-(4-fluorostyryl)-5-(phenylsulfonyl)pyridine | Drug Info | [528690] | |||
(R)-(+)-(4,5,6-trimethoxyindan-1-yl)methanamine | Drug Info | [528294] | |||
(R)-(-)-11-hydroxy-N-n-propylnoraporphine | Drug Info | [529686] | |||
(R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | Drug Info | [528778] | |||
(R)-3-(4-propylmorpholin-2-yl)phenol | Drug Info | [529128] | |||
(R,S)-1-(5-bromo-1H-indol-1-yl)propan-2-amine | Drug Info | [551219] | |||
(R,S)-1-(5-chloro-1H-indol-1-yl)propan-2-amine | Drug Info | [551219] | |||
(R,S)-1-(5-fluoro-1H-indol-1-yl)propan-2-amine | Drug Info | [551219] | |||
(R,S)-1-(5-methyl-1H-indol-1-yl)propan-2-amine | Drug Info | [551219] | |||
(R,S)-1-(6-fluoro-1H-indol-1-yl)propan-2-amine | Drug Info | [551219] | |||
(S)-(-)-(4,5,6-trimethoxyindan-1-yl)methanamine | Drug Info | [528294] | |||
(S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine | Drug Info | [551219] | |||
1,2,3,4-Tetrahydro-naphthalen-2-ylamine | Drug Info | [533482] | |||
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole | Drug Info | [526235] | |||
1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-m-tolylpiperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-phenylpiperazin-1-yl)hexane | Drug Info | [530927] | |||
1-((R)-2-aminopropyl)-1H-indazol-6-ol | Drug Info | [527952] | |||
1-((S)-2-aminopropyl)-1H-indazol-6-ol | Drug Info | [527952] | |||
1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol | Drug Info | [527952] | |||
1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | Drug Info | [527952] | |||
1-((S)-2-aminopropyl)-7-iodo-1H-indazol-6-ol | Drug Info | [527952] | |||
1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol | Drug Info | [527952] | |||
1-(10-Bromoanthracen-9-yl)-2-aminopropane | Drug Info | [529336] | |||
1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine | Drug Info | [533476] | |||
1-(2,5-Dimethoxy-phenyl)-piperazine | Drug Info | [533476] | |||
1-(2,5-dimethoxyphenyl)propan-2-amine | Drug Info | [529336] | |||
1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine | Drug Info | [529336] | |||
1-(2-aminoethyl)-1H-indazol-6-ol | Drug Info | [527952] | |||
1-(2-Methoxy-phenyl)-4-propyl-piperazine | Drug Info | [533873] | |||
1-(2-Methoxy-phenyl)-piperazine | Drug Info | [533476] | |||
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine | Drug Info | [529013] | |||
1-(3-(phenylthio)propyl)-4-m-tolylpiperazine | Drug Info | [528625] | |||
1-(3-Trifluoromethyl-phenyl)-piperazine | Drug Info | [533476] | |||
1-(4-Bromo-2,5-difluorophenyl)-2-aminopropane | Drug Info | [529336] | |||
1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine | Drug Info | [533476] | |||
1-(4-ethyl-2,5-dimethoxyphenyl)propan-2-amine | Drug Info | [529336] | |||
1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol | Drug Info | [527668] | |||
1-Butyl-4-(2-methoxy-phenyl)-piperazine | Drug Info | [533873] | |||
1-Ethyl-4-(2-methoxy-phenyl)-piperazine | Drug Info | [533873] | |||
1-methoxy-9-aminomethyl-9,10-dihydroanthracene | Drug Info | [529672] | |||
1-Methyl-1,3-dihydro-indol-2-one | Drug Info | [526055] | |||
1-Naphthalen-1-yl-piperazine | Drug Info | [533482] | |||
1-Naphthalen-2-yl-piperazine | Drug Info | [533482] | |||
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine | Drug Info | [551334] | |||
11-Butyryloxy-N-n-propylnoraporphine | Drug Info | [529686] | |||
11-Heptanoyloxy-N-n-propylnoraporphine | Drug Info | [529686] | |||
11-Hexanoyloxy-N-n-propylnoraporphine | Drug Info | [529686] | |||
11-Propionyloxy-N-n-propylnoraporphine | Drug Info | [529686] | |||
11-valeryloxynoraporphine | Drug Info | [529686] | |||
2,2-Diphenyl-ethylamine | Drug Info | [525993] | |||
2,5-dimethoxy-4-bromophenethylamine | Drug Info | [528433] | |||
2-(1H-indol-3-yl)-N,N-dimethylethanamine | Drug Info | [529336] | |||
2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol | Drug Info | [533498] | |||
2-(2-Methoxy-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(3,5-dimethoxy-4-phenethoxyphenyl)ethanamine | Drug Info | [529336] | |||
2-(3-Methoxy-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(4-Bromo-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine | Drug Info | [551319] | |||
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine | Drug Info | [527952] | |||
2-(9,10-dihydroanthracen-9-yl)-N-methylethanamine | Drug Info | [530331] | |||
2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | Drug Info | [530516] | |||
2-methoxy-9-aminomethyl-9,10-dihydroanthracene | Drug Info | [529672] | |||
2-Phenyl-3-(2-piperidin-1-yl-ethyl)-1H-indole | Drug Info | [525940] | |||
2-Phenyl-3-piperidin-4-yl-1H-indole | Drug Info | [525940] | |||
2-Piperazin-1-yl-phenol | Drug Info | [533476] | |||
3-(1-Benzyl-piperidin-4-yl)-2-phenyl-1H-indole | Drug Info | [525940] | |||
3-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-indole | Drug Info | [525940] | |||
3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole | Drug Info | [525940] | |||
3-(2-Amino-propyl)-1H-indol-5-ol | Drug Info | [527952] | |||
3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol | Drug Info | [527668] | |||
3-(2-Dimethylamino-ethyl)-1H-indol-6-ol | Drug Info | [527668] | |||
3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-ol | Drug Info | [527668] | |||
3-(2-Dimethylamino-propyl)-1H-indol-4-ol | Drug Info | [527668] | |||
3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol | Drug Info | [527668] | |||
3-(3-Dimethylamino-propyl)-1H-indol-4-ol | Drug Info | [527668] | |||
3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one | Drug Info | [533476] | |||
3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol | Drug Info | [527668] | |||
3-Dimethylaminomethyl-1H-indol-4-ol | Drug Info | [527668] | |||
3-methoxy-9-aminomethyl-9,10-dihydroanthracene | Drug Info | [529672] | |||
3-Naphthalen-1-yl-1-propyl-pyrrolidine | Drug Info | [551334] | |||
3-Naphthalen-1-yl-pyrrolidine | Drug Info | [551334] | |||
4,4-Diphenylbutan-1-amine | Drug Info | [530331] | |||
4-(10H-Anthracen-9-ylidene)-1-methyl-piperidine | Drug Info | [525993] | |||
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one | Drug Info | [531079] | |||
4-(4-Fluoro-benzyl)-piperidine hydrochloride | Drug Info | [526959] | |||
4-Benzyl-1-methyl-piperidine hydrochloride | Drug Info | [526959] | |||
4-methoxy-9-aminomethyl-9,10-dihydroanthracene | Drug Info | [529672] | |||
5,6-dichloro-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526899] | |||
5-chloro-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide | Drug Info | [551219] | |||
5-MEO-DMT | Drug Info | [527952] | |||
5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526899] | |||
5-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [526899] | |||
5-METHOXYTRYPTAMINE | Drug Info | [533464] | |||
6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine | Drug Info | [529221] | |||
6-bromoaplysinopsin | Drug Info | [526321] | |||
6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole | Drug Info | [526235] | |||
6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide | Drug Info | [551219] | |||
6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526899] | |||
7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine | Drug Info | [529221] | |||
7,8,9,10-tetrahydro-6H-furo-[3,2-g][3]benzazepine | Drug Info | [529221] | |||
7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole | Drug Info | [526235] | |||
7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526899] | |||
8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526899] | |||
8-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [526899] | |||
8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole | Drug Info | [526235] | |||
8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526899] | |||
8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline | Drug Info | [533482] | |||
8-Methoxy-2-piperazin-1-yl-quinoline | Drug Info | [533482] | |||
8-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [526899] | |||
9-(2-aminoethyl)-9,10-dihydroanthracene | Drug Info | [530331] | |||
9-(2-aminopropyl)-9,10-dihydroanthracene | Drug Info | [530331] | |||
9-(Aminomethyl)-9,10-dihydroanthracene | Drug Info | [525993] | |||
9-(N-benzylaminomethyl)-9,10-dihydroanthracene | Drug Info | [530613] | |||
A-80426 | Drug Info | [527799] | |||
A-987306 | Drug Info | [529789] | |||
ALTANSERIN | Drug Info | [530045] | |||
Aniracetam | Drug Info | [551390] | |||
APLYSINOPSIN | Drug Info | [551219] | |||
BARETTIN | Drug Info | [528498] | |||
Brolamfetamine | Drug Info | [529463] | |||
C-(5-bromo-4,7-dimethoxyindan-1-yl)methylamine | Drug Info | [528433] | |||
C-(5H-Dibenzo[a,d]cyclohepten-5-yl)-methylamine | Drug Info | [525993] | |||
C-(9H-Thioxanthen-9-yl)-methylamine | Drug Info | [525993] | |||
C-(9H-Xanthen-9-yl)-methylamine | Drug Info | [525993] | |||
CHLOROPHENYLPIPERAZINE | Drug Info | [530589] | |||
CINANSERIN | Drug Info | [533464] | |||
Dimethyltryptamine | Drug Info | [551401] | |||
DOM | Drug Info | [529336] | |||
Etisulergine | Drug Info | [533501] | |||
FLUANISONE | Drug Info | [533378] | |||
ISOCLOZAPINE | Drug Info | [534532] | |||
LY433222 | Drug Info | [536286] | |||
LYSERGIC ACID DIETHYLAMIDE | Drug Info | [528294] | |||
MAZAPERTINE | Drug Info | [533800] | |||
MDL-11939 | Drug Info | [526959] | |||
MDL-28161 | Drug Info | [526959] | |||
MESCALINE | Drug Info | [529336] | |||
N,N-dimethyl-2,2-diphenylethanamine | Drug Info | [530331] | |||
N,N-Dimethyl-3,3-diphenylpropan-1-amine | Drug Info | [530331] | |||
N,N-dimethyl-4,4-diphenylbutan-1-amine | Drug Info | [530331] | |||
N-(1-(1-phenylethyl)piperidin-4-yl)-1-naphthamide | Drug Info | [528639] | |||
N-(1-(1-phenylethyl)piperidin-4-yl)-2-naphthamide | Drug Info | [528639] | |||
N-(1-(3-bromobenzyl)piperidin-4-yl)-1-naphthamide | Drug Info | [528638] | |||
N-(1-(3-bromobenzyl)piperidin-4-yl)-2-naphthamide | Drug Info | [528638] | |||
N-(1-(4-bromobenzyl)piperidin-4-yl)-2-naphthamide | Drug Info | [528638] | |||
N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide | Drug Info | [528638] | |||
N-(1-(4-phenylbutyl)piperidin-4-yl)-1-naphthamide | Drug Info | [528639] | |||
N-(1-(4-phenylbutyl)piperidin-4-yl)-2-naphthamide | Drug Info | [528639] | |||
N-(1-benzylpiperidine-4-yl)-2-naphthamide | Drug Info | [528638] | |||
N-(1-phenethylpiperidin-4-yl)-1-naphthamide | Drug Info | [528639] | |||
N-(1-phenethylpiperidin-4-yl)-2-naphthamide | Drug Info | [528639] | |||
N-3'-ethylaplysinopsin | Drug Info | [526321] | |||
N-methyl-3,3-diphenylpropan-1-amine | Drug Info | [530331] | |||
N-methyl-4,4-diphenylbutan-1-amine | Drug Info | [530331] | |||
PG-01037 | Drug Info | [528974] | |||
PHENETHYLAMINE | Drug Info | [525993] | |||
PHENYLPIPERAZINE | Drug Info | [533482] | |||
PSILOCIN | Drug Info | [529336] | |||
QUIPAZINE | Drug Info | [530451] | |||
Racemic DOI | Drug Info | [529336] | |||
Racemic DOTFM | Drug Info | [529336] | |||
Ro-60-0175 | Drug Info | [529168] | |||
RP-68303 | Drug Info | [534052] | |||
SB-271046 | Drug Info | [529191] | |||
SEROTONIN | Drug Info | [530451] | |||
SPIPERONE | Drug Info | [534417] | |||
TIOSPIRONE | Drug Info | [534093] | |||
TRYPTAMINE | Drug Info | [533464] | |||
TRYPTOLINE | Drug Info | [526899] | |||
VER-2692 | Drug Info | [527833] | |||
VER-3323 | Drug Info | [527037] | |||
VER-5384 | Drug Info | [527037] | |||
VER-5593 | Drug Info | [527037] | |||
VOLINANSERIN | Drug Info | [530045] | |||
WAY-208466 | Drug Info | [530209] | |||
YM-348 | Drug Info | [529221] | |||
YM-992 | Drug Info | [536286] | |||
ZOTEPINE | Drug Info | [525963] | |||
[2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine | Drug Info | [527668] | |||
[2-(6-Methoxy-indol-1-yl)-ethyl]-dimethyl-amine | Drug Info | [526235] | |||
Antagonist | 1192U90 | Drug Info | [536463] | ||
9-OH-risperidone | Drug Info | [534281] | |||
Adatanserin | Drug Info | [534942], [536580] | |||
AMESERGIDE | Drug Info | [526792], [533907] | |||
Blonanserin | Drug Info | [536463] | |||
bufotenine | Drug Info | [534136] | |||
BVT.28949 | Drug Info | [526792], [544175] | |||
cyamemazine | Drug Info | [526510] | |||
EGIS-7625 | Drug Info | [527053] | |||
Fananserin | Drug Info | [536463] | |||
FCE-22716 | Drug Info | [526792], [533340] | |||
GMC-283 | Drug Info | [536463] | |||
Iloperidone | Drug Info | [530677], [536463] | |||
ITI-007 | Drug Info | [551041] | |||
Low dose ITI-007 | Drug Info | [526792], [551041] | |||
LY063518 | Drug Info | [534232] | |||
LY108742 | Drug Info | [533905] | |||
LY215840 | Drug Info | [533905] | |||
LY314228 | Drug Info | [534232] | |||
LY320954 | Drug Info | [534232] | |||
LY53857 | Drug Info | [535896], [535927], [536352], [538142] | |||
LY86057 | Drug Info | [533905] | |||
M100907 | Drug Info | [535134] | |||
metergoline | Drug Info | [527178] | |||
MIN-101 | Drug Info | [526792] | |||
MPDT | Drug Info | [525722] | |||
norfluoxetine | Drug Info | [525929] | |||
Org-23366 | Drug Info | [536463] | |||
Ritanserin | Drug Info | [536752], [536787], [538142] | |||
Sarpogrelate | Drug Info | [537172], [537535], [538037] | |||
SB 215505 | Drug Info | [525458] | |||
SB 221284 | Drug Info | [527178] | |||
SB 228357 | Drug Info | [525730] | |||
SB 242084 | Drug Info | [534428] | |||
SERAZAPINE HYDROCHLORIDE | Drug Info | [526792], [533896] | |||
SERGOLEXOLE MALEATE | Drug Info | [526792], [533252] | |||
spiramide | Drug Info | [527178] | |||
TNX-102 | Drug Info | [551739] | |||
[11C]volinanserin | Drug Info | [525893] | |||
[18F]altanserin | Drug Info | [534323] | |||
[3H]fananserin | Drug Info | [534046] | |||
[3H]N-methylspiperone | Drug Info | [525890] | |||
Modulator | Abaperidone | Drug Info | [553290] | ||
AMPEROZIDE | Drug Info | ||||
ATI-9242 | Drug Info | [526792], [550651] | |||
Deramciclane | Drug Info | [534609] | |||
DUP-734 | Drug Info | ||||
EPLIVANSERIN MESILATE | Drug Info | ||||
Flibanserin | Drug Info | [532651] | |||
ICI-169369 | Drug Info | ||||
Iferanserin-Ventrus | Drug Info | [543891] | |||
Lurasidone hydrochloride | Drug Info | [530859], [531351] | |||
NELOTANSERIN | Drug Info | ||||
Ocaperidone | Drug Info | [526792] | |||
Pimavanserin | Drug Info | ||||
PRUVANSERIN | Drug Info | [552847] | |||
R-102444 | Drug Info | [535964] | |||
SEL-73 | Drug Info | [526792] | |||
SL65.0472 | Drug Info | ||||
SR46349B | Drug Info | ||||
Very low dose (VLD) cyclobenzaprine | Drug Info | [526792] | |||
YKP-1358 | Drug Info | [528644] | |||
Zicronapine | Drug Info | [549861] | |||
Binder | SKL-10406 | Drug Info | [544111] | ||
ZD-3638 | Drug Info | [536463] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channels | |||||
PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | ||||
G alpha (q) signalling events | |||||
WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
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Ref 544590 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000237) | ||||
Ref 544618 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000314) | ||||
Ref 544679 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000562) | ||||
Ref 544701 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000669) | ||||
Ref 544709 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000690) | ||||
Ref 544716 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000706) | ||||
Ref 544787 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001117) | ||||
Ref 544867 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001373) | ||||
Ref 544876 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001395) | ||||
Ref 544913 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001479) | ||||
Ref 544961 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001723) | ||||
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Ref 545055 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001984) | ||||
Ref 545274 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002662) | ||||
Ref 545423 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003204) | ||||
Ref 546043 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006017) | ||||
Ref 546447 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008166) | ||||
Ref 546467 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008324) | ||||
Ref 547235 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014343) | ||||
Ref 547242 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014358) | ||||
Ref 547301 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014997) | ||||
Ref 547365 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015510) | ||||
Ref 547459 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016551) | ||||
Ref 547624 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017946) | ||||
Ref 548083 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021795) | ||||
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