Target Information

Target General Infomation
Target ID
T32060
Former ID
TTDS00103
Target Name
5-hydroxytryptamine 2A receptor
Gene Name
HTR2A
Synonyms
5-HT-2; 5-HT-2A; 5-HT2A receptor; 5-hydroxytryptamine receptor 2A; Serotonin receptor; Serotonin receptor 2A; HTR2A
Target Type
Successful
Disease Addiction [ICD code not available]
Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Cardiovascular disorder [ICD10: I00-I99]
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63]
Central nervous system disease [ICD10: G00-G99]
Diabetes [ICD9: 253.5, 588.1; ICD10: E23.2, N25.1]
Depression [ICD9: 311; ICD10: F30-F39]
Erythropoietic porphyria [ICD10: E80.0]
Female sexual dysfunction [ICD9: 302.7; ICD10: F52]
Fibromyalgia [ICD9: 729.1; ICD10: M79.7]
Glaucoma [ICD9: 365; ICD10: H40-H42]
Hypertension [ICD9: 401; ICD10: I10-I16]
Hemorrhoids [ICD10: I84]
Migraine [ICD9: 346; ICD10: G43]
Mood disorder [ICD10: F30-F39]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Psychiatric disorder [ICD9: 290-319; ICD10: F01-F99]
Pancreatitis [ICD9: 577.0-577.1; ICD10: K85, K86.0K86.1]
Parkinson's disease; Psychosis; Schizophrenia [ICD9:290-299, 332, 295; ICD10: F02.3, F20-F29, G20, F20]
Parkinson disease psychosis [ICD10: G00-G99]
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
Schizophrenia [ICD9: 295; ICD10: F20]
Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10: F51, G47]
Schizophrenia; Sleep maintenance insomnia [ICD9:295, 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F20, F51.0, G47.0]
Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10: F20, F25]
Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia [ICD9: 295, 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F20, F51.0, G47.0]
Severe mood disorders [ICD9: 296; ICD10: F30-F39]
Unspecified [ICD code not available]
Function
G-protein coupled receptor for5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
BioChemical Class
GPCR rhodopsin
Target Validation
T32060
UniProt ID
P28223
Sequence
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Drugs and Mode of Action
Drug(s) Abilify Maintena Drug Info Approved Erythropoietic porphyria [551871]
Aniracetam Drug Info Approved Cerebrovascular ischaemia [467478], [526084]
Flibanserin Drug Info Approved Mood disorder [532651], [542987]
Iloperidone Drug Info Approved Schizophrenia [530677], [543255]
Lurasidone hydrochloride Drug Info Approved Schizophrenia [530859], [531351], [542486], [551871]
Pimavanserin Drug Info Approved Parkinson disease psychosis [889440]
Sarpogrelate Drug Info Approved Diabetes [535855], [539330]
ZOTEPINE Drug Info Approved Anxiety disorder [538628], [551871]
Blonanserin Drug Info Phase 3 Schizophrenia [536463], [542649]
Flibanserin Drug Info Phase 3 Female sexual dysfunction [536493], [542987]
ITI-007 Drug Info Phase 3 Schizophrenia; Sleep maintenance insomnia [525226], [549912]
Low dose ITI-007 Drug Info Phase 3 Schizophrenia [548546]
M100907 Drug Info Phase 3 Sleep disorders [522054]
Pimavanserin Drug Info Phase 3 Parkinson's disease; Psychosis; Schizophrenia [543125], [547301]
SR46349B Drug Info Phase 3 Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia [536463]
TNX-102 Drug Info Phase 3 Fibromyalgia [547624]
TRYPTAMINE Drug Info Phase 3 Discovery agent [521730], [538764]
VOLINANSERIN Drug Info Phase 3 Discovery agent [522480], [539159]
Zicronapine Drug Info Phase 3 Schizophrenia [523357]
BVT.28949 Drug Info Phase 2 Glaucoma [548204]
Ocaperidone Drug Info Phase 2 Schizophrenia; Schizoaffective disorders [467839], [526792], [536463]
PRUVANSERIN Drug Info Phase 2 Sleep disorders [521764]
1192U90 Drug Info Phase 1 Psychotic disorders [534252]
Abaperidone Drug Info Phase 1 Schizophrenia [551815]
MIN-101 Drug Info Phase 1 Schizophrenia [524902]
SKL-10406 Drug Info Phase 1 Major depressive disorder [549136]
Temanogrel Drug Info Phase 1 Cardiovascular disorder [524599]
YKP-1358 Drug Info Phase 1 Schizophrenia; Schizoaffective disorders [536463]
Org-23366 Drug Info Preclinical Schizophrenia [536463]
LYSERGIC ACID DIETHYLAMIDE Drug Info Withdrawn from market Addiction [526769], [539053]
Deramciclane Drug Info Discontinued in Phase 3 Anxiety disorder [540889], [544913]
Iferanserin-Ventrus Drug Info Discontinued in Phase 3 Hemorrhoids [547235]
MDL-11939 Drug Info Discontinued in Phase 3 Anxiety disorder [539169], [544618]
Ritanserin Drug Info Discontinued in Phase 3 Anxiety disorder [543335], [544590]
TIOSPIRONE Drug Info Discontinued in Phase 3 Discovery agent [538617], [544679]
Adatanserin Drug Info Discontinued in Phase 2 Severe mood disorders [536580]
AMESERGIDE Drug Info Discontinued in Phase 2 Mood disorder [539285], [544787]
ATI-9242 Drug Info Discontinued in Phase 2 Schizophrenia [548733]
FCE-22716 Drug Info Discontinued in Phase 2 Hypertension [533340]
MAZAPERTINE Drug Info Discontinued in Phase 2 Discovery agent [545274]
NELOTANSERIN Drug Info Discontinued in Phase 2 Sleep disorders [548083]
SERAZAPINE HYDROCHLORIDE Drug Info Discontinued in Phase 2 Anxiety disorder [544867]
SERGOLEXOLE MALEATE Drug Info Discontinued in Phase 2 Migraine [544716]
SL65.0472 Drug Info Discontinued in Phase 2 Cardiovascular disorder [547242]
YM-992 Drug Info Discontinued in Phase 2 Depression [546447]
AM-831 Drug Info Discontinued in Phase 1 Schizophrenia [547459]
DUP-734 Drug Info Discontinued in Phase 1 Psychotic disorders [544981]
1192U90 Drug Info Terminated Schizophrenia [536463]
A-80426 Drug Info Terminated Discovery agent [546043]
AMPEROZIDE Drug Info Terminated Alcohol use disorders [544701]
DV-7028 Drug Info Terminated Cardiovascular disorder [545055]
Fananserin Drug Info Terminated Schizophrenia [536463], [540837]
GMC-283 Drug Info Terminated Schizophrenia [536463]
ICI-169369 Drug Info Terminated Anxiety disorder [539780], [544709]
LY53857 Drug Info Terminated Discovery agent [539138], [544876]
MDL-28161 Drug Info Terminated Discovery agent [544961]
R-102444 Drug Info Terminated Pancreatitis [547365]
Ro-60-0175 Drug Info Terminated Discovery agent [539026], [546467]
RP-68303 Drug Info Terminated Discovery agent [545423]
ZD-3638 Drug Info Terminated Schizophrenia [536463]
Agonist (+)-LSD Drug Info [527178]
3,4-Methylenedioxymethamphetamine Drug Info [551382]
5-CT Drug Info [527178]
Abilify Maintena Drug Info [526792], [527134]
ACP-106 Drug Info [526792]
AL-37350A Drug Info [526713]
alpha-methyl-5-HT Drug Info [525890]
AM-831 Drug Info [550322]
BRL-15572 Drug Info [534475]
BW723C86 Drug Info [527178]
DV-7028 Drug Info [537955], [538116], [538117]
LP-12 Drug Info [528956]
LP-44 Drug Info [528956]
m-chlorophenylpiperazine Drug Info [534830]
MMDA Drug Info [551393]
N-1-isopropyl-5-MeOT Drug Info [533905]
N-1-isopropyltryptamine Drug Info [533905]
Org 12962 Drug Info [527178]
SB 216641 Drug Info [534475]
Temanogrel Drug Info [526792], [550267]
TFMPP Drug Info [527178]
[125I]DOI Drug Info [525927]
Inhibitor (+/-)-nantenine Drug Info [530558]
(1-Phenethyl-piperidin-4-yl)-phenyl-methanone Drug Info [525963]
(2-Indol-1-yl-ethyl)-dimethyl-amine Drug Info [526235]
(2S)-1-(1H-furo[2,3-g]indazol-1-yl)propan-2-amine Drug Info [529168]
(2S)-1-(5-fluoro-1H-indazol-1-yl)propan-2-amine Drug Info [529168]
(2S)-1-(6-fluoro-1H-indazol-1-yl)propan-2-amine Drug Info [529168]
(2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine Drug Info [527952]
(E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine Drug Info [528690]
(E)-2-(4-fluorostyryl)-5-(phenylsulfonyl)pyridine Drug Info [528690]
(R)-(+)-(4,5,6-trimethoxyindan-1-yl)methanamine Drug Info [528294]
(R)-(-)-11-hydroxy-N-n-propylnoraporphine Drug Info [529686]
(R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Drug Info [528778]
(R)-3-(4-propylmorpholin-2-yl)phenol Drug Info [529128]
(R,S)-1-(5-bromo-1H-indol-1-yl)propan-2-amine Drug Info [551219]
(R,S)-1-(5-chloro-1H-indol-1-yl)propan-2-amine Drug Info [551219]
(R,S)-1-(5-fluoro-1H-indol-1-yl)propan-2-amine Drug Info [551219]
(R,S)-1-(5-methyl-1H-indol-1-yl)propan-2-amine Drug Info [551219]
(R,S)-1-(6-fluoro-1H-indol-1-yl)propan-2-amine Drug Info [551219]
(S)-(-)-(4,5,6-trimethoxyindan-1-yl)methanamine Drug Info [528294]
(S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine Drug Info [551219]
1,2,3,4-Tetrahydro-naphthalen-2-ylamine Drug Info [533482]
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole Drug Info [526235]
1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-m-tolylpiperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-phenylpiperazin-1-yl)hexane Drug Info [530927]
1-((R)-2-aminopropyl)-1H-indazol-6-ol Drug Info [527952]
1-((S)-2-aminopropyl)-1H-indazol-6-ol Drug Info [527952]
1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol Drug Info [527952]
1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol Drug Info [527952]
1-((S)-2-aminopropyl)-7-iodo-1H-indazol-6-ol Drug Info [527952]
1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol Drug Info [527952]
1-(10-Bromoanthracen-9-yl)-2-aminopropane Drug Info [529336]
1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine Drug Info [533476]
1-(2,5-Dimethoxy-phenyl)-piperazine Drug Info [533476]
1-(2,5-dimethoxyphenyl)propan-2-amine Drug Info [529336]
1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine Drug Info [529336]
1-(2-aminoethyl)-1H-indazol-6-ol Drug Info [527952]
1-(2-Methoxy-phenyl)-4-propyl-piperazine Drug Info [533873]
1-(2-Methoxy-phenyl)-piperazine Drug Info [533476]
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine Drug Info [529013]
1-(3-(phenylthio)propyl)-4-m-tolylpiperazine Drug Info [528625]
1-(3-Trifluoromethyl-phenyl)-piperazine Drug Info [533476]
1-(4-Bromo-2,5-difluorophenyl)-2-aminopropane Drug Info [529336]
1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine Drug Info [533476]
1-(4-ethyl-2,5-dimethoxyphenyl)propan-2-amine Drug Info [529336]
1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol Drug Info [527668]
1-Butyl-4-(2-methoxy-phenyl)-piperazine Drug Info [533873]
1-Ethyl-4-(2-methoxy-phenyl)-piperazine Drug Info [533873]
1-methoxy-9-aminomethyl-9,10-dihydroanthracene Drug Info [529672]
1-Methyl-1,3-dihydro-indol-2-one Drug Info [526055]
1-Naphthalen-1-yl-piperazine Drug Info [533482]
1-Naphthalen-2-yl-piperazine Drug Info [533482]
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine Drug Info [551334]
11-Butyryloxy-N-n-propylnoraporphine Drug Info [529686]
11-Heptanoyloxy-N-n-propylnoraporphine Drug Info [529686]
11-Hexanoyloxy-N-n-propylnoraporphine Drug Info [529686]
11-Propionyloxy-N-n-propylnoraporphine Drug Info [529686]
11-valeryloxynoraporphine Drug Info [529686]
2,2-Diphenyl-ethylamine Drug Info [525993]
2,5-dimethoxy-4-bromophenethylamine Drug Info [528433]
2-(1H-indol-3-yl)-N,N-dimethylethanamine Drug Info [529336]
2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol Drug Info [533498]
2-(2-Methoxy-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(3,5-dimethoxy-4-phenethoxyphenyl)ethanamine Drug Info [529336]
2-(3-Methoxy-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(4-Bromo-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine Drug Info [551319]
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine Drug Info [527952]
2-(9,10-dihydroanthracen-9-yl)-N-methylethanamine Drug Info [530331]
2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline Drug Info [530516]
2-methoxy-9-aminomethyl-9,10-dihydroanthracene Drug Info [529672]
2-Phenyl-3-(2-piperidin-1-yl-ethyl)-1H-indole Drug Info [525940]
2-Phenyl-3-piperidin-4-yl-1H-indole Drug Info [525940]
2-Piperazin-1-yl-phenol Drug Info [533476]
3-(1-Benzyl-piperidin-4-yl)-2-phenyl-1H-indole Drug Info [525940]
3-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-indole Drug Info [525940]
3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole Drug Info [525940]
3-(2-Amino-propyl)-1H-indol-5-ol Drug Info [527952]
3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol Drug Info [527668]
3-(2-Dimethylamino-ethyl)-1H-indol-6-ol Drug Info [527668]
3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-ol Drug Info [527668]
3-(2-Dimethylamino-propyl)-1H-indol-4-ol Drug Info [527668]
3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol Drug Info [527668]
3-(3-Dimethylamino-propyl)-1H-indol-4-ol Drug Info [527668]
3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one Drug Info [533476]
3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol Drug Info [527668]
3-Dimethylaminomethyl-1H-indol-4-ol Drug Info [527668]
3-methoxy-9-aminomethyl-9,10-dihydroanthracene Drug Info [529672]
3-Naphthalen-1-yl-1-propyl-pyrrolidine Drug Info [551334]
3-Naphthalen-1-yl-pyrrolidine Drug Info [551334]
4,4-Diphenylbutan-1-amine Drug Info [530331]
4-(10H-Anthracen-9-ylidene)-1-methyl-piperidine Drug Info [525993]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [531079]
4-(4-Fluoro-benzyl)-piperidine hydrochloride Drug Info [526959]
4-Benzyl-1-methyl-piperidine hydrochloride Drug Info [526959]
4-methoxy-9-aminomethyl-9,10-dihydroanthracene Drug Info [529672]
5,6-dichloro-3,4-dihydroquinazolin-2-amine Drug Info [529148]
5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [526899]
5-chloro-3,4-dihydroquinazolin-2-amine Drug Info [529148]
5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide Drug Info [551219]
5-MEO-DMT Drug Info [527952]
5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [526899]
5-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info [526899]
5-METHOXYTRYPTAMINE Drug Info [533464]
6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine Drug Info [529221]
6-bromoaplysinopsin Drug Info [526321]
6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole Drug Info [526235]
6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide Drug Info [551219]
6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [526899]
7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine Drug Info [529221]
7,8,9,10-tetrahydro-6H-furo-[3,2-g][3]benzazepine Drug Info [529221]
7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole Drug Info [526235]
7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [526899]
8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [526899]
8-Bromo-4,9-dihydro-3H-beta-carboline Drug Info [526899]
8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole Drug Info [526235]
8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [526899]
8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline Drug Info [533482]
8-Methoxy-2-piperazin-1-yl-quinoline Drug Info [533482]
8-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info [526899]
9-(2-aminoethyl)-9,10-dihydroanthracene Drug Info [530331]
9-(2-aminopropyl)-9,10-dihydroanthracene Drug Info [530331]
9-(Aminomethyl)-9,10-dihydroanthracene Drug Info [525993]
9-(N-benzylaminomethyl)-9,10-dihydroanthracene Drug Info [530613]
A-80426 Drug Info [527799]
A-987306 Drug Info [529789]
ALTANSERIN Drug Info [530045]
Aniracetam Drug Info [551390]
APLYSINOPSIN Drug Info [551219]
BARETTIN Drug Info [528498]
Brolamfetamine Drug Info [529463]
C-(5-bromo-4,7-dimethoxyindan-1-yl)methylamine Drug Info [528433]
C-(5H-Dibenzo[a,d]cyclohepten-5-yl)-methylamine Drug Info [525993]
C-(9H-Thioxanthen-9-yl)-methylamine Drug Info [525993]
C-(9H-Xanthen-9-yl)-methylamine Drug Info [525993]
CHLOROPHENYLPIPERAZINE Drug Info [530589]
CINANSERIN Drug Info [533464]
Dimethyltryptamine Drug Info [551401]
DOM Drug Info [529336]
Etisulergine Drug Info [533501]
FLUANISONE Drug Info [533378]
ISOCLOZAPINE Drug Info [534532]
LY433222 Drug Info [536286]
LYSERGIC ACID DIETHYLAMIDE Drug Info [528294]
MAZAPERTINE Drug Info [533800]
MDL-11939 Drug Info [526959]
MDL-28161 Drug Info [526959]
MESCALINE Drug Info [529336]
N,N-dimethyl-2,2-diphenylethanamine Drug Info [530331]
N,N-Dimethyl-3,3-diphenylpropan-1-amine Drug Info [530331]
N,N-dimethyl-4,4-diphenylbutan-1-amine Drug Info [530331]
N-(1-(1-phenylethyl)piperidin-4-yl)-1-naphthamide Drug Info [528639]
N-(1-(1-phenylethyl)piperidin-4-yl)-2-naphthamide Drug Info [528639]
N-(1-(3-bromobenzyl)piperidin-4-yl)-1-naphthamide Drug Info [528638]
N-(1-(3-bromobenzyl)piperidin-4-yl)-2-naphthamide Drug Info [528638]
N-(1-(4-bromobenzyl)piperidin-4-yl)-2-naphthamide Drug Info [528638]
N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide Drug Info [528638]
N-(1-(4-phenylbutyl)piperidin-4-yl)-1-naphthamide Drug Info [528639]
N-(1-(4-phenylbutyl)piperidin-4-yl)-2-naphthamide Drug Info [528639]
N-(1-benzylpiperidine-4-yl)-2-naphthamide Drug Info [528638]
N-(1-phenethylpiperidin-4-yl)-1-naphthamide Drug Info [528639]
N-(1-phenethylpiperidin-4-yl)-2-naphthamide Drug Info [528639]
N-3'-ethylaplysinopsin Drug Info [526321]
N-methyl-3,3-diphenylpropan-1-amine Drug Info [530331]
N-methyl-4,4-diphenylbutan-1-amine Drug Info [530331]
PG-01037 Drug Info [528974]
PHENETHYLAMINE Drug Info [525993]
PHENYLPIPERAZINE Drug Info [533482]
PSILOCIN Drug Info [529336]
QUIPAZINE Drug Info [530451]
Racemic DOI Drug Info [529336]
Racemic DOTFM Drug Info [529336]
Ro-60-0175 Drug Info [529168]
RP-68303 Drug Info [534052]
SB-271046 Drug Info [529191]
SEROTONIN Drug Info [530451]
SPIPERONE Drug Info [534417]
TIOSPIRONE Drug Info [534093]
TRYPTAMINE Drug Info [533464]
TRYPTOLINE Drug Info [526899]
VER-2692 Drug Info [527833]
VER-3323 Drug Info [527037]
VER-5384 Drug Info [527037]
VER-5593 Drug Info [527037]
VOLINANSERIN Drug Info [530045]
WAY-208466 Drug Info [530209]
YM-348 Drug Info [529221]
YM-992 Drug Info [536286]
ZOTEPINE Drug Info [525963]
[2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine Drug Info [527668]
[2-(6-Methoxy-indol-1-yl)-ethyl]-dimethyl-amine Drug Info [526235]
Antagonist 1192U90 Drug Info [536463]
9-OH-risperidone Drug Info [534281]
Adatanserin Drug Info [534942], [536580]
AMESERGIDE Drug Info [526792], [533907]
Blonanserin Drug Info [536463]
bufotenine Drug Info [534136]
BVT.28949 Drug Info [526792], [544175]
cyamemazine Drug Info [526510]
EGIS-7625 Drug Info [527053]
Fananserin Drug Info [536463]
FCE-22716 Drug Info [526792], [533340]
GMC-283 Drug Info [536463]
Iloperidone Drug Info [530677], [536463]
ITI-007 Drug Info [551041]
Low dose ITI-007 Drug Info [526792], [551041]
LY063518 Drug Info [534232]
LY108742 Drug Info [533905]
LY215840 Drug Info [533905]
LY314228 Drug Info [534232]
LY320954 Drug Info [534232]
LY53857 Drug Info [535896], [535927], [536352], [538142]
LY86057 Drug Info [533905]
M100907 Drug Info [535134]
metergoline Drug Info [527178]
MIN-101 Drug Info [526792]
MPDT Drug Info [525722]
norfluoxetine Drug Info [525929]
Org-23366 Drug Info [536463]
Ritanserin Drug Info [536752], [536787], [538142]
Sarpogrelate Drug Info [537172], [537535], [538037]
SB 215505 Drug Info [525458]
SB 221284 Drug Info [527178]
SB 228357 Drug Info [525730]
SB 242084 Drug Info [534428]
SERAZAPINE HYDROCHLORIDE Drug Info [526792], [533896]
SERGOLEXOLE MALEATE Drug Info [526792], [533252]
spiramide Drug Info [527178]
TNX-102 Drug Info [551739]
[11C]volinanserin Drug Info [525893]
[18F]altanserin Drug Info [534323]
[3H]fananserin Drug Info [534046]
[3H]N-methylspiperone Drug Info [525890]
Modulator Abaperidone Drug Info [553290]
AMPEROZIDE Drug Info
ATI-9242 Drug Info [526792], [550651]
Deramciclane Drug Info [534609]
DUP-734 Drug Info
EPLIVANSERIN MESILATE Drug Info
Flibanserin Drug Info [532651]
ICI-169369 Drug Info
Iferanserin-Ventrus Drug Info [543891]
Lurasidone hydrochloride Drug Info [530859], [531351]
NELOTANSERIN Drug Info
Ocaperidone Drug Info [526792]
Pimavanserin Drug Info
PRUVANSERIN Drug Info [552847]
R-102444 Drug Info [535964]
SEL-73 Drug Info [526792]
SL65.0472 Drug Info
SR46349B Drug Info
Very low dose (VLD) cyclobenzaprine Drug Info [526792]
YKP-1358 Drug Info [528644]
Zicronapine Drug Info [549861]
Binder SKL-10406 Drug Info [544111]
ZD-3638 Drug Info [536463]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
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